3,4-seco-Diterpenoids from Trigonostemon flavidus
Tang, Gui-Hua1,2; He, Hong-Ping1; Gu, Yu-Cheng3; Di, Ying-Tong1; Wang, Yue-Hu4; Li, Shi-Fei1,2; Li, Shun-Lin1; Zhang, Yu1; Hao, Xiao-Jiang1
Corresponding AuthorZhang, Y (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China.,zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
2012-11-25
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume68Issue:47Pages:9679-9684
Abstract

Phytochemical investigation on the stems of Trigonostemon flavidus resulted in the isolation of five new 3,4-seco-diterpenoids, trigoflavidones A-E (1-5), structurally related to the main co-occurring known 3,4-seco-sonderianic acid (6) and 3,4-seco-sonderianol (7). Compound 4 possesses new 3,4-seco rearranged ent-pimarane skeletal type, characteristic of a vinyl group at C-8, while 5 features a unique five-membered ring (C-1) fused with a cyclopropane ring (C-2). The structures of the new compounds were established by a combination of spectroscopic data and computational methods. Compounds 1-7 were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines. (c) 2012 Elsevier Ltd. All rights reserved.

KeywordEuphorbiaceae Trigonostemon Flavidus Trigoflavidones A-e 3 4-seco-diterpenoids
Subject AreaChemistry, Organic
DOI10.1016/j.tet.2012.09.052
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000310402400021
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15908
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Tang, Gui-Hua,He, Hong-Ping,Gu, Yu-Cheng,et al. 3,4-seco-Diterpenoids from Trigonostemon flavidus[J]. TETRAHEDRON,2012,68(47):9679-9684.
APA Tang, Gui-Hua.,He, Hong-Ping.,Gu, Yu-Cheng.,Di, Ying-Tong.,Wang, Yue-Hu.,...&Hao, Xiao-Jiang.(2012).3,4-seco-Diterpenoids from Trigonostemon flavidus.TETRAHEDRON,68(47),9679-9684.
MLA Tang, Gui-Hua,et al."3,4-seco-Diterpenoids from Trigonostemon flavidus".TETRAHEDRON 68.47(2012):9679-9684.
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