A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis
Jiang, Zhi-Yong; Zhang, Xue-Mei; Zhang, Feng-Xue; Liu, Ni; Zhao, Fang; Zhou, Jun; Chen, Ji-Jun
2006-08-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号72期号:10页码:951-954
摘要A new triterpencid named alisol 0 (1) was isolated from the rhizomes of Alisma orientalis, together with six known compounds: alisol A 24-acetate (2), 25-anhydroalisol A (3),13 beta,17 beta-epoxyalisol A (4), alisol B 23-acetate (5), alisol F (6), and alisol F 24-acetate (7). Based on 1D and 2D-NMR data (HMQC, HMBC, COSY, ROESY), the structure of the new compound was deduced to be 11-dehydroxy-12-dehydroalisol F-24-acetate (1). Compounds 2-7 exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 2.3,11.0,15.4,14.3, 0.6 and 7.7 mu M, and on HBV e antigen (HBeAg) secretion with IC50 values of 498.1, 17.6, 41.0,19.9, 8.5 and 5.1 mu M, respectively.
关键词Protostane-type Triterpenes Absolute Stereostructures Aquatic Plants Crude Drugs Rhizoma Sesquiterpenes Constituents 23-acetate Alismoxide
学科领域Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-2006-947178
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000240478500019
引用统计
被引频次:81[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1583
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Guangzhou Univ Chinese Tradit Med, Inst Trop Med Sci, Guangzhou, Peoples R China
3.Chinese Acad Sci, Joint Lab Anti Viral Nat Med, Kunming Branch, Kunming 650204, Yunnan, Peoples R China
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Jiang, Zhi-Yong,Zhang, Xue-Mei,Zhang, Feng-Xue,et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis[J]. PLANTA MEDICA,2006,72(10):951-954.
APA Jiang, Zhi-Yong.,Zhang, Xue-Mei.,Zhang, Feng-Xue.,Liu, Ni.,Zhao, Fang.,...&Chen, Ji-Jun.(2006).A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis.PLANTA MEDICA,72(10),951-954.
MLA Jiang, Zhi-Yong,et al."A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis".PLANTA MEDICA 72.10(2006):951-954.
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