A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis

doi:10.1055/s-2006-947178

	A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis
	Jiang, Zhi-Yong ; Zhang, Xue-Mei; Zhang, Feng-Xue ; Liu, Ni ; Zhao, Fang ; Zhou, Jun; Chen, Ji-Jun
	2006-08-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	72 期号:10 页码:951-954
摘要	A new triterpencid named alisol 0 (1) was isolated from the rhizomes of Alisma orientalis, together with six known compounds: alisol A 24-acetate (2), 25-anhydroalisol A (3),13 beta,17 beta-epoxyalisol A (4), alisol B 23-acetate (5), alisol F (6), and alisol F 24-acetate (7). Based on 1D and 2D-NMR data (HMQC, HMBC, COSY, ROESY), the structure of the new compound was deduced to be 11-dehydroxy-12-dehydroalisol F-24-acetate (1). Compounds 2-7 exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 2.3,11.0,15.4,14.3, 0.6 and 7.7 mu M, and on HBV e antigen (HBeAg) secretion with IC50 values of 498.1, 17.6, 41.0,19.9, 8.5 and 5.1 mu M, respectively.
关键词	Protostane-type Triterpenes Absolute Stereostructures Aquatic Plants Crude Drugs Rhizoma Sesquiterpenes Constituents 23-acetate Alismoxide
学科领域	Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI	10.1055/s-2006-947178
收录类别	SCI
语种	英语
WOS记录号	WOS:000240478500019
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1583
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Guangzhou Univ Chinese Tradit Med, Inst Trop Med Sci, Guangzhou, Peoples R China 3.Chinese Acad Sci, Joint Lab Anti Viral Nat Med, Kunming Branch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Zhi-Yong,Zhang, Xue-Mei,Zhang, Feng-Xue,et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis[J]. PLANTA MEDICA,2006,72(10):951-954.
APA	Jiang, Zhi-Yong.,Zhang, Xue-Mei.,Zhang, Feng-Xue.,Liu, Ni.,Zhao, Fang.,...&Chen, Ji-Jun.(2006).A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis.PLANTA MEDICA,72(10),951-954.
MLA	Jiang, Zhi-Yong,et al."A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis".PLANTA MEDICA 72.10(2006):951-954.

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