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题名: A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis
作者: Jiang, Zhi-Yong; Zhang, Xue-Mei; Zhang, Feng-Xue; Liu, Ni; Zhao, Fang; Zhou, Jun; null(陈纪军)
刊名: PLANTA MEDICA
关键词: PROTOSTANE-TYPE TRITERPENES ; ABSOLUTE STEREOSTRUCTURES ; AQUATIC PLANTS ; CRUDE DRUGS ; RHIZOMA ; SESQUITERPENES ; CONSTITUENTS ; 23-ACETATE ; ALISMOXIDE
英文摘要: A new triterpencid named alisol 0 (1) was isolated from the rhizomes of Alisma orientalis, together with six known compounds: alisol A 24-acetate (2), 25-anhydroalisol A (3),13 beta,17 beta-epoxyalisol A (4), alisol B 23-acetate (5), alisol F (6), and alisol F 24-acetate (7). Based on 1D and 2D-NMR data (HMQC, HMBC, COSY, ROESY), the structure of the new compound was deduced to be 11-dehydroxy-12-dehydroalisol F-24-acetate (1). Compounds 2-7 exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 2.3,11.0,15.4,14.3, 0.6 and 7.7 mu M, and on HBV e antigen (HBeAg) secretion with IC50 values of 498.1, 17.6, 41.0,19.9, 8.5 and 5.1 mu M, respectively.
出版日期: 2006-08-01
卷号: 72, 期号:10, 页码:951-954
DOI标识: 10.1055/s-2006-947178
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry; Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1583
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Guangzhou Univ Chinese Tradit Med, Inst Trop Med Sci, Guangzhou, Peoples R China
3.Chinese Acad Sci, Joint Lab Anti Viral Nat Med, Kunming Branch, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Jiang, ZY; Zhang, XM; Zhang, FX; Liu, N; Zhao, F; Zhou, J; Chen, JJ.A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis,PLANTA MEDICA,2006,72(10):951-954
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