Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber
Gao, Na1,2,3; Wu, Mingyi1; Liu, Shao2,3; Lian, Wu1; Li, Zi1; Zhao, Jinhua1
2012-08-01
发表期刊MARINE DRUGS
ISSN1660-3397 ; 1660-3397
卷号10期号:8页码:1647-1661
摘要Fucosylated chondroitin sulfate (FuCS), a kind of complex glycosaminoglycan from sea cucumber, has potent anticoagulant activity. In order to understand the relationship between structures and activity, the depolymerized FuCS (dFuCS) was chosen to prepare its derivates by selective substitution at OH groups. Its O-acylation was carried out in a homogeneous way using carboxylic acid anhydrides. The structures of O-acylated derivatives were characterized by NMR. The results indicated that the 4-O-sulfated fucose residues may be easier to be acylated than the other ones in the sulfated fucose branches. But the O-acylation was always accompanied by the beta-elimination, and the degree of elimination was higher as that of acylation was higher. The results of clotting assay indicated that the effect of partial O-acylation of the dFuCS on their anticoagulant potency was not significant and the O-acylation of 2-OH groups of 4-O-sulfated fucose units did not affect the anticoagulant activity.
关键词Sea Cucumber Fucosylated Chondroitin Sulfate Glycosaminoglycan Acylation Anticoagulant Activity
资助信息Yunnan Provincial Science and Technology Department in China [2010CI116]; West Light Foundation of the Chinese Academy of Sciences; National Natural Science Foundation of China [81102372]; Yunnan Provincial Science and Technology Department in China [2010CI116]; West Light Foundation of the Chinese Academy of Sciences; National Natural Science Foundation of China [81102372]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15722
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Cent S Univ, Sch Pharmaceut Sci, Changsha 410078, Hunan, Peoples R China
3.Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China
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GB/T 7714
Gao, Na,Wu, Mingyi,Liu, Shao,et al. Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber[J]. MARINE DRUGS,2012,10(8):1647-1661.
APA Gao, Na,Wu, Mingyi,Liu, Shao,Lian, Wu,Li, Zi,&Zhao, Jinhua.(2012).Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber.MARINE DRUGS,10(8),1647-1661.
MLA Gao, Na,et al."Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber".MARINE DRUGS 10.8(2012):1647-1661.
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