| Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber | |
Gao, Na1,2,3; Wu, Mingyi1; Liu, Shao2,3; Lian, Wu1; Li, Zi1; Zhao, Jinhua1
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| 通讯作者 | Zhao, JH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China.,gn2008.happy@163.com ; Zhao, JH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China.,gn2008.happy@163.com ; mingyiwu_tju@yahoo.com ; mingyiwu_tju@yahoo.com ; liushao999@hotmail.com ; liushao999@hotmail.com ; lw3662410@yahoo.com.cn ; lw3662410@yahoo.com.cn ; Lizi_08@126.com ; Lizi_08@126.com ; zhao.jinhua@yahoo.com ; zhao.jinhua@yahoo.com |
| 2012-08-01 | |
| 发表期刊 | MARINE DRUGS
 |
| ISSN | 1660-3397 ; 1660-3397 |
| 卷号 | 10期号:8页码:1647-1661 |
| 摘要 | Fucosylated chondroitin sulfate (FuCS), a kind of complex glycosaminoglycan from sea cucumber, has potent anticoagulant activity. In order to understand the relationship between structures and activity, the depolymerized FuCS (dFuCS) was chosen to prepare its derivates by selective substitution at OH groups. Its O-acylation was carried out in a homogeneous way using carboxylic acid anhydrides. The structures of O-acylated derivatives were characterized by NMR. The results indicated that the 4-O-sulfated fucose residues may be easier to be acylated than the other ones in the sulfated fucose branches. But the O-acylation was always accompanied by the beta-elimination, and the degree of elimination was higher as that of acylation was higher. The results of clotting assay indicated that the effect of partial O-acylation of the dFuCS on their anticoagulant potency was not significant and the O-acylation of 2-OH groups of 4-O-sulfated fucose units did not affect the anticoagulant activity. |
| 关键词 | Sea Cucumber Fucosylated Chondroitin Sulfate Glycosaminoglycan Acylation Anticoagulant Activity |
| DOI | 10.3390/md10081647 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308207400003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15722 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Cent S Univ, Sch Pharmaceut Sci, Changsha 410078, Hunan, Peoples R China 3.Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Na,Wu, Mingyi,Liu, Shao,et al. Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber[J]. MARINE DRUGS,2012,10(8):1647-1661. |
| APA | Gao, Na,Wu, Mingyi,Liu, Shao,Lian, Wu,Li, Zi,&Zhao, Jinhua.(2012).Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber.MARINE DRUGS,10(8),1647-1661. |
| MLA | Gao, Na,et al."Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber".MARINE DRUGS 10.8(2012):1647-1661. |
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