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题名: Chemical Constituents of Saniculiphyllum guangxiense
作者: Geng, Chang-An1; Huang, Xiao-Yan1; Lei, Li-Gong2; Zhang, Xue-Mei1; null(陈纪军)1
刊名: CHEMISTRY & BIODIVERSITY
关键词: Saniculiphyllum guangxiense ; Nitrile glucosides ; Triterpenoids ; Glucosides ; Antiviral activity ; X-Ray crystallography
英文摘要: The first phytochemical investigation on Saniculiphyllum guangxiense resulted in the isolation of two new triterpenoids, 16 beta-hydroxybryodulcosigenin (3) and 3a-O-feruloylolean-12-en-27-oic acid (6), together with six known compounds, menisdaurin (1), purshianin (2), oleanolic acid (4), 3 beta-hydroxyolean-12-en-27-oic acid (5), beta-sitosterol (7), and daucosterol (8), which were characterized by extensive spectroscopic analyses and in one case by X-ray diffraction. According to this primary investigation, S. guangxiense is rich in nitrile glucosides and triterpenoids, of which menisdaurin (1; 0.06%) and purshianin (2; 0.015%) are the main constituents. Compounds 16 were assayed for their anti-hepatitis B virus (HBV) activities against the secretion of HBsAg and HBeAg, as well as HBV DNA replication on Hep G 2.2.15 cell line in vitro. The most active compound, menisdaurin (1), inhibits HBV DNA replication with an IC50 value of 0.32 mM (SI>11.97).
出版日期: 2012-08-01
卷号: 9, 期号:8, 页码:1508-1516
DOI标识: 10.1002/cbdv.201100270
语种: 英语
ISSN号: 1612-1872
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15716
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Heilongtan 650201, Kunming, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Biodivers & Biogeog, Heilongtan 650201, Kunming, Peoples R China

Recommended Citation:
Geng, Chang-An; Huang, Xiao-Yan; Lei, Li-Gong; Zhang, Xue-Mei; Chen, Ji-Jun.Chemical Constituents of Saniculiphyllum guangxiense,CHEMISTRY & BIODIVERSITY,2012,9(8):1508-1516
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