Chemical Constituents of Saniculiphyllum guangxiense
Geng, Chang-An1; Huang, Xiao-Yan1; Lei, Li-Gong2; Zhang, Xue-Mei1; Chen, Ji-Jun1
2012-08-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号9期号:8页码:1508-1516
摘要The first phytochemical investigation on Saniculiphyllum guangxiense resulted in the isolation of two new triterpenoids, 16 beta-hydroxybryodulcosigenin (3) and 3a-O-feruloylolean-12-en-27-oic acid (6), together with six known compounds, menisdaurin (1), purshianin (2), oleanolic acid (4), 3 beta-hydroxyolean-12-en-27-oic acid (5), beta-sitosterol (7), and daucosterol (8), which were characterized by extensive spectroscopic analyses and in one case by X-ray diffraction. According to this primary investigation, S. guangxiense is rich in nitrile glucosides and triterpenoids, of which menisdaurin (1; 0.06%) and purshianin (2; 0.015%) are the main constituents. Compounds 16 were assayed for their anti-hepatitis B virus (HBV) activities against the secretion of HBsAg and HBeAg, as well as HBV DNA replication on Hep G 2.2.15 cell line in vitro. The most active compound, menisdaurin (1), inhibits HBV DNA replication with an IC50 value of 0.32 mM (SI>11.97).
关键词Saniculiphyllum Guangxiense Nitrile Glucosides Triterpenoids Glucosides Antiviral Activity X-ray Crystallography
资助信息National Natural Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China [30770152]; Major Project of Innovative Engineering [KSCX2-YW-R-181]
DOI10.1002/cbdv.201100270
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000307773700011
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15716
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Heilongtan 650201, Kunming, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Biodivers & Biogeog, Heilongtan 650201, Kunming, Peoples R China
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GB/T 7714
Geng, Chang-An,Huang, Xiao-Yan,Lei, Li-Gong,et al. Chemical Constituents of Saniculiphyllum guangxiense[J]. CHEMISTRY & BIODIVERSITY,2012,9(8):1508-1516.
APA Geng, Chang-An,Huang, Xiao-Yan,Lei, Li-Gong,Zhang, Xue-Mei,&Chen, Ji-Jun.(2012).Chemical Constituents of Saniculiphyllum guangxiense.CHEMISTRY & BIODIVERSITY,9(8),1508-1516.
MLA Geng, Chang-An,et al."Chemical Constituents of Saniculiphyllum guangxiense".CHEMISTRY & BIODIVERSITY 9.8(2012):1508-1516.
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