Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea
Xu, Jun-Ju1,2; Huang, Huo-Qiang1; Zeng, Guang-Zhi1; Tan, Ning-Hua1
2012-09-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号83期号:6页码:1125-1130
摘要Two new sesquiterpenes deltoiden A (1) and deltoiden B (2), and two new lignans deltoignan A (9) and deltoignan B (10), together with 14 known compounds, including six sesquiterpenes 3-8 and three lignans 11-13, were isolated from the whole plant of Saussurea deltoidea. Compounds 3-8 and 11-17 were isolated for the first time from this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1-13 were tested against three cancer cell lines A549, Hela and SMMC-7721. Results showed that 5,6 and 7 exhibited cytotoxicity against SMMC-7721 with the IC50 values of 6.49, 9.53, 1.23 mu g/ml, 5 and 7 against A549 with the IC50 values of 4.99 and 5.35 mu g/ml, 5,6,7,13 against Hela with the IC50 values of 1.40, 4.75, 0.93 and 5.42 mu g/ml, respectively. The structure-activity relationships of sesquiterpenes 1-8 were discussed on the base of cytotoxic results. (C) 2012 Elsevier B.V. All rights reserved.
关键词Asteraceae Siussurea Deltoidea Sesquiterpe Nes Lgnans Cytotoxicity
资助信息National Natural Science Foundation of China [U1032602, 31000159, 91013002, 30725048]; National New Drug Innovation Major Project of China [2011ZX09307-002-002]; National Basic Research Program of China [2009CB522300]
DOI10.1016/j.fitote.2012.04.022
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000308116600025
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15710
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China
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Xu, Jun-Ju,Huang, Huo-Qiang,Zeng, Guang-Zhi,et al. Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea[J]. FITOTERAPIA,2012,83(6):1125-1130.
APA Xu, Jun-Ju,Huang, Huo-Qiang,Zeng, Guang-Zhi,&Tan, Ning-Hua.(2012).Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea.FITOTERAPIA,83(6),1125-1130.
MLA Xu, Jun-Ju,et al."Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea".FITOTERAPIA 83.6(2012):1125-1130.
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