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题名: Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea
作者: Xu, Jun-Ju1, 2; Huang, Huo-Qiang1; Zeng, Guang-Zhi1; Tan, Ning-Hua1
刊名: FITOTERAPIA
关键词: Asteraceae ; Siussurea deltoidea ; Sesquiterpe nes ; Lgnans ; Cytotoxicity
英文摘要: Two new sesquiterpenes deltoiden A (1) and deltoiden B (2), and two new lignans deltoignan A (9) and deltoignan B (10), together with 14 known compounds, including six sesquiterpenes 3-8 and three lignans 11-13, were isolated from the whole plant of Saussurea deltoidea. Compounds 3-8 and 11-17 were isolated for the first time from this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1-13 were tested against three cancer cell lines A549, Hela and SMMC-7721. Results showed that 5,6 and 7 exhibited cytotoxicity against SMMC-7721 with the IC50 values of 6.49, 9.53, 1.23 mu g/ml, 5 and 7 against A549 with the IC50 values of 4.99 and 5.35 mu g/ml, 5,6,7,13 against Hela with the IC50 values of 1.40, 4.75, 0.93 and 5.42 mu g/ml, respectively. The structure-activity relationships of sesquiterpenes 1-8 were discussed on the base of cytotoxic results. (C) 2012 Elsevier B.V. All rights reserved.
出版日期: 2012-09-01
卷号: 83, 期号:6, 页码:1125-1130
DOI标识: 10.1016/j.fitote.2012.04.022
语种: 英语
收录类别: SCI
ISSN号: 0367-326X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15710
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China

Recommended Citation:
Xu, Jun-Ju; Huang, Huo-Qiang; Zeng, Guang-Zhi; Tan, Ning-Hua.Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea,FITOTERAPIA,2012,83(6):1125-1130
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