Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans
Xu, You-Kai1; Liao, Shang-Gao2; Na, Zhi3; Hu, Hua-Bin1; Li, Yan4; Luo, Huai-Rong4
2012-09-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号83期号:6页码:1120-1124
摘要Bioassay-guided isolation of the stems of Gelsemium elegans has led to the isolation of two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), and two known alkaloids, koumine (3) and gelselegine (4). The structures of 1-2 were determined by spectroscopic (for both) and single-crystal X-ray diffraction (for 1) analysis. All compounds isolated were evaluated for their potential as immunosuppressive agents and the data suggested that Gelsemium alkaloids of different structural types possibly have potential as immunosuppressive agents. (C) 2012 Elsevier B.V. All rights reserved.
关键词Gelsemium Elegant 21-(2-oxopropyl)-koumine 11-methoxygelselegine Immunosuppressive Activity
资助信息key project of the Tropical Characteristic Medical Resources Branch Research Centre of the Chinese Academy of Sciences [KSCX2-YW-R-172]
DOI10.1016/j.fitote.2012.04.023
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000308116600024
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15708
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Xishuangbanna Trop Bot Garden, CAS Key Lab Trop Forest Ecol, Mengla 666303, Yunnan Province, Peoples R China
2.Guiyang Med Coll, Sch Pharm, Guiyang 550004, Peoples R China
3.Chinese Acad Sci, Lab Trop Plant Resource Sci, Xishuangbanna Trop Bot Garden, Mengla 666303, Yunnan Province, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
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Xu, You-Kai,Liao, Shang-Gao,Na, Zhi,et al. Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans[J]. FITOTERAPIA,2012,83(6):1120-1124.
APA Xu, You-Kai,Liao, Shang-Gao,Na, Zhi,Hu, Hua-Bin,Li, Yan,&Luo, Huai-Rong.(2012).Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans.FITOTERAPIA,83(6),1120-1124.
MLA Xu, You-Kai,et al."Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans".FITOTERAPIA 83.6(2012):1120-1124.
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