Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida
Shen, Shi1; Zhu, Huajie2; Chen, Dawei1; Liu, Dong1; van Ofwegen, Leen3; Proksch, Peter4; Lin, Wenhan1
2012-10-24
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号53期号:43页码:5759-5762
摘要Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Soft Coral Sinularia Pavida Pavidolides A-e Structural Elucidation Antifouling Activity Cytotoxic Activity
资助信息NSFC [30930109]; National Innovation Project [2009ZX09501-014, 2009ZX09103-140]; CMST Projects [2010DFA31610]
DOI10.1016/j.tetlet.2012.08.049
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000309618000010
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15690
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Natl Museum Nat Hist Nat, NL-2300 RA Leiden, Netherlands
4.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
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Shen, Shi,Zhu, Huajie,Chen, Dawei,et al. Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida[J]. TETRAHEDRON LETTERS,2012,53(43):5759-5762.
APA Shen, Shi.,Zhu, Huajie.,Chen, Dawei.,Liu, Dong.,van Ofwegen, Leen.,...&Lin, Wenhan.(2012).Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida.TETRAHEDRON LETTERS,53(43),5759-5762.
MLA Shen, Shi,et al."Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida".TETRAHEDRON LETTERS 53.43(2012):5759-5762.
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