| Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida | |
| Shen, Shi1; Zhu, Huajie2; Chen, Dawei1; Liu, Dong1; van Ofwegen, Leen3; Proksch, Peter4; Lin, Wenhan1 | |
| 通讯作者 | Lin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.,whlin@bjmu.edu.cn |
| 2012-10-24 | |
| 发表期刊 | TETRAHEDRON LETTERS
 |
| ISSN | 0040-4039 |
| 卷号 | 53期号:43页码:5759-5762 |
| 摘要 | Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. (C) 2012 Elsevier Ltd. All rights reserved. |
| 关键词 | Soft Coral Sinularia Pavida Pavidolides A-e Structural Elucidation Antifouling Activity Cytotoxic Activity |
| DOI | 10.1016/j.tetlet.2012.08.049 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000309618000010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15690 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Natl Museum Nat Hist Nat, NL-2300 RA Leiden, Netherlands 4.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany |
| 推荐引用方式 GB/T 7714 | Shen, Shi,Zhu, Huajie,Chen, Dawei,et al. Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida[J]. TETRAHEDRON LETTERS,2012,53(43):5759-5762. |
| APA | Shen, Shi.,Zhu, Huajie.,Chen, Dawei.,Liu, Dong.,van Ofwegen, Leen.,...&Lin, Wenhan.(2012).Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida.TETRAHEDRON LETTERS,53(43),5759-5762. |
| MLA | Shen, Shi,et al."Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida".TETRAHEDRON LETTERS 53.43(2012):5759-5762. |
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