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题名: Anti-HIV activities of extracts from Pu-erh tea
作者: Huang Ning1, 4; Yang Liu-Meng1; Li Xiao-Li2; Zheng Chang-Bo3; Wang Rui-Rui1; Yang Yongping(杨永平)2; Zheng Yong-Tang1
刊名: CHINESE JOURNAL OF NATURAL MEDICINES
关键词: Tea ; Camellia sinensis ; Pu-erh Tea ; Anti-HIV agents
英文摘要: AIM: To evaluate the anti-HIV activities of extracts from two commonly forms of Pu-erh tea (fermented), green tea-like (unfermented). METHODS: The cytotoxicities of extracts on C8166, MT4 and PBMC were assessed by MTT and the anti-HIV activities of extracts were evaluated by syncytium reduction and p24 antigen assay. RESULTS: All extracts had low cytotoxicities with the CC50 from 120.63 to 524.95 mu g.mL(-1). All extracts can inhibit HIV-induced cytopathic effects, with EC50 various from 11.13 to 67.49 mu g.mL(-1). The WEPT's were better than EEPTs, moreover the FPT's water extracts were better than the GTLPT's especially YYP-31 with SI value 42.40. YYP-31 also inhibited HIV-1(RF) and HIV-2(CBL-20) infection with EC50 of 30.82 and 39.79 mu g.mL(-1), respectively. YYP-31 reduced p24 antigen expression in HIV-1(IIIB) acute infected C8166 and in HIV-1(KM018) infected PBMC with EC50 values of 14.95 and 74.63 mu g.mL(-1), respectively. YYP-31 blocked the fusion between normal C8166 cells and HIV-1 chronically infected H9 cells with EC50 values of 234.27 mu g.mL(-1). It exhibits markedly synergistic anti-HIV activity in combination with AZT but can't inhibit activities of reverse transcriptase. CONCLUSION: Pu-erh tea extracts exhibit highly efficient anti-HIV-1 activity and can be considered to be used to as a complementary therapy or a health product to HIV patients.
出版日期: 2012-09-01
卷号: 10, 期号:5, 页码:347-352
语种: 英语
收录类别: SCI
ISSN号: 1672-3651
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15664
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming 650204, Peoples R China
3.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Huang Ning; Yang Liu-Meng; Li Xiao-Li; Zheng Chang-Bo; Wang Rui-Rui; Yang Yong-Ping; Zheng Yong-Tang.Anti-HIV activities of extracts from Pu-erh tea,CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(5):347-352
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