Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola
Wu, Ying-Rui; Ma, Yun-Bao; Zhao, You-Xing; Yao, Shu-Ying; Zhou, Jun; Zhou, Ying; Chen, Ji-Jun
2007-07-01
Source PublicationPLANTA MEDICA
ISSN0032-0943
Volume73Issue:8Pages:787-791
AbstractTwo new quaternary isoquinoline alkaloids, saxicolalines A (1) and N-methylnarceimicine (2), together with sixteen known alkaloids (3-18) were isolated from Corydalis saxicola Bunting. The structures of saxicolalines A (1) and N-methylnarceimicine (2) were established based on spectral methods including 1D, 2D NMR (COSY, HMQC, HMBC) and HR-ESI-MS. The anti-HBV activities of ten main alkaloids were evaluated. Among the tested compounds, dihydrochelerythrine (8) exhibited the most potent activity against HBsAg and HBeAg secretions with IC50 < 0.05 mu M, SI > 3.5, respectively.
KeywordCorydalis Saxicola Bunting Fumariaceae Quaternary Isoquinoline Alkaloids Anti-hbv Activity
Subject AreaPlant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-2007-981549
Indexed BySCI
Language英语
WOS IDWOS:000248437500013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1549
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Guangxi Inst Chinese Med & Pharmaceut Sci, Nanning, Peoples R China
Recommended Citation
GB/T 7714
Wu, Ying-Rui,Ma, Yun-Bao,Zhao, You-Xing,et al. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola[J]. PLANTA MEDICA,2007,73(8):787-791.
APA Wu, Ying-Rui.,Ma, Yun-Bao.,Zhao, You-Xing.,Yao, Shu-Ying.,Zhou, Jun.,...&Chen, Ji-Jun.(2007).Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola.PLANTA MEDICA,73(8),787-791.
MLA Wu, Ying-Rui,et al."Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola".PLANTA MEDICA 73.8(2007):787-791.
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