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题名: Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola
作者: Wu, Ying-Rui; Ma, Yun-Bao; Zhao, You-Xing; Yao, Shu-Ying; Zhou, Jun; Zhou, Ying; null(陈纪军)
刊名: PLANTA MEDICA
关键词: corydalis saxicola Bunting ; Fumariaceae ; quaternary isoquinoline ; alkaloids ; anti-HBV activity
英文摘要: Two new quaternary isoquinoline alkaloids, saxicolalines A (1) and N-methylnarceimicine (2), together with sixteen known alkaloids (3-18) were isolated from Corydalis saxicola Bunting. The structures of saxicolalines A (1) and N-methylnarceimicine (2) were established based on spectral methods including 1D, 2D NMR (COSY, HMQC, HMBC) and HR-ESI-MS. The anti-HBV activities of ten main alkaloids were evaluated. Among the tested compounds, dihydrochelerythrine (8) exhibited the most potent activity against HBsAg and HBeAg secretions with IC50 < 0.05 mu M, SI > 3.5, respectively.
出版日期: 2007-07-01
卷号: 73, 期号:8, 页码:787-791
DOI标识: 10.1055/s-2007-981549
语种: 英语
ISSN号: 0032-0943
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1549
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Guangxi Inst Chinese Med & Pharmaceut Sci, Nanning, Peoples R China

Recommended Citation:
Wu, YR; Ma, YB; Zhao, YX; Yao, SY; Zhou, J; Zhou, Y; Chen, JJ.Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola,PLANTA MEDICA,2007,73(8):787-791
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