Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola

doi:10.1055/s-2007-981549

	Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola
	Wu, Ying-Rui ; Ma, Yun-Bao ; Zhao, You-Xing ; Yao, Shu-Ying ; Zhou, Jun; Zhou, Ying ; Chen, Ji-Jun
	2007-07-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	73 期号:8 页码:787-791
摘要	Two new quaternary isoquinoline alkaloids, saxicolalines A (1) and N-methylnarceimicine (2), together with sixteen known alkaloids (3-18) were isolated from Corydalis saxicola Bunting. The structures of saxicolalines A (1) and N-methylnarceimicine (2) were established based on spectral methods including 1D, 2D NMR (COSY, HMQC, HMBC) and HR-ESI-MS. The anti-HBV activities of ten main alkaloids were evaluated. Among the tested compounds, dihydrochelerythrine (8) exhibited the most potent activity against HBsAg and HBeAg secretions with IC50 < 0.05 mu M, SI > 3.5, respectively.
关键词	Corydalis Saxicola Bunting Fumariaceae Quaternary Isoquinoline Alkaloids Anti-hbv Activity
学科领域	Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI	10.1055/s-2007-981549
收录类别	SCI
语种	英语
WOS记录号	WOS:000248437500013
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1549
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Guangxi Inst Chinese Med & Pharmaceut Sci, Nanning, Peoples R China
推荐引用方式 GB/T 7714	Wu, Ying-Rui,Ma, Yun-Bao,Zhao, You-Xing,et al. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola[J]. PLANTA MEDICA,2007,73(8):787-791.
APA	Wu, Ying-Rui.,Ma, Yun-Bao.,Zhao, You-Xing.,Yao, Shu-Ying.,Zhou, Jun.,...&Chen, Ji-Jun.(2007).Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola.PLANTA MEDICA,73(8),787-791.
MLA	Wu, Ying-Rui,et al."Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola".PLANTA MEDICA 73.8(2007):787-791.

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