Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola
Wu, Ying-Rui; Ma, Yun-Bao; Zhao, You-Xing; Yao, Shu-Ying; Zhou, Jun; Zhou, Ying; Chen, Ji-Jun
2007-07-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号73期号:8页码:787-791
摘要Two new quaternary isoquinoline alkaloids, saxicolalines A (1) and N-methylnarceimicine (2), together with sixteen known alkaloids (3-18) were isolated from Corydalis saxicola Bunting. The structures of saxicolalines A (1) and N-methylnarceimicine (2) were established based on spectral methods including 1D, 2D NMR (COSY, HMQC, HMBC) and HR-ESI-MS. The anti-HBV activities of ten main alkaloids were evaluated. Among the tested compounds, dihydrochelerythrine (8) exhibited the most potent activity against HBsAg and HBeAg secretions with IC50 < 0.05 mu M, SI > 3.5, respectively.
关键词Corydalis Saxicola Bunting Fumariaceae Quaternary Isoquinoline Alkaloids Anti-hbv Activity
学科领域Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-2007-981549
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000248437500013
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1549
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Guangxi Inst Chinese Med & Pharmaceut Sci, Nanning, Peoples R China
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Wu, Ying-Rui,Ma, Yun-Bao,Zhao, You-Xing,et al. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola[J]. PLANTA MEDICA,2007,73(8):787-791.
APA Wu, Ying-Rui.,Ma, Yun-Bao.,Zhao, You-Xing.,Yao, Shu-Ying.,Zhou, Jun.,...&Chen, Ji-Jun.(2007).Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola.PLANTA MEDICA,73(8),787-791.
MLA Wu, Ying-Rui,et al."Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola".PLANTA MEDICA 73.8(2007):787-791.
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