| Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme | |
Shen, YH; Weng, ZY; Zhao, QS ; Zeng, YQ; Rios, J; Xiao, WL; Xu, G; Sun, HD
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| 通讯作者 | Sun, HD (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kumming Inst Bot, Heilongtan 650204, Kuming, Peoples R China. hdsun@mail.kib.ac.cn |
| 2005-08-01 | |
| 发表期刊 | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| 卷号 | 71期号:8页码:770-775 |
| 摘要 | Five new oleanane-type triterpene saponins, named foenumosides A (1), B (2), C (3), D (4) and E (5), were isolated from the aerial parts of Lysimachia foenum-graecum Hance. Their structures were identified on the basis of 1D and 2D NMR techniques, including H-H COSY, HMQC, HMBC, HMQC-TOCSY, ROESY experiments as well as chemical methods. We have evaluated the cytotoxity of 1-5 against rat and human polymorphonuclear leukocytes and the effect of 5 on the arachidonic acid metabolizing enzyme. All compounds showed a high degree of toxicity except for compound 5, while 5 notably reduced the production of leukotriene B-4 (LTB4) from rat peritoneal leukocytes with an IC50 value of 74 mu M without inhibiting human elastase. Compound 5 also reduced the production of 12-HHTrE and 12-HETE by 14% and 50% as a measurement for cyclooxygenase-1 and 12-lipoxygenase inhibition at 100 mu M. |
| 关键词 | Lysimachia Foenum-graecum Saponin Triterpene Glycosides Arachidonic Acid |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1055/s-2005-871289 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000231863000016 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15436 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kumming Inst Bot, Heilongtan 650204, Kuming, Peoples R China 2.Univ Valencia, Fac Farm, Dept Farmacol, Burjassot, Valencia, Spain 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, YH,Weng, ZY,Zhao, QS,et al. Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme[J]. PLANTA MEDICA,2005,71(8):770-775. |
| APA | Shen, YH.,Weng, ZY.,Zhao, QS.,Zeng, YQ.,Rios, J.,...&Sun, HD.(2005).Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme.PLANTA MEDICA,71(8),770-775. |
| MLA | Shen, YH,et al."Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme".PLANTA MEDICA 71.8(2005):770-775. |
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