Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme
Shen, YH; Weng, ZY; Zhao, QS; Zeng, YQ; Rios, J; Xiao, WL; Xu, G; Sun, HD
2005-08-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号71期号:8页码:770-775
摘要Five new oleanane-type triterpene saponins, named foenumosides A (1), B (2), C (3), D (4) and E (5), were isolated from the aerial parts of Lysimachia foenum-graecum Hance. Their structures were identified on the basis of 1D and 2D NMR techniques, including H-H COSY, HMQC, HMBC, HMQC-TOCSY, ROESY experiments as well as chemical methods. We have evaluated the cytotoxity of 1-5 against rat and human polymorphonuclear leukocytes and the effect of 5 on the arachidonic acid metabolizing enzyme. All compounds showed a high degree of toxicity except for compound 5, while 5 notably reduced the production of leukotriene B-4 (LTB4) from rat peritoneal leukocytes with an IC50 value of 74 mu M without inhibiting human elastase. Compound 5 also reduced the production of 12-HHTrE and 12-HETE by 14% and 50% as a measurement for cyclooxygenase-1 and 12-lipoxygenase inhibition at 100 mu M.
关键词Lysimachia Foenum-graecum Saponin Triterpene Glycosides Arachidonic Acid
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-2005-871289
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000231863000016
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15436
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kumming Inst Bot, Heilongtan 650204, Kuming, Peoples R China
2.Univ Valencia, Fac Farm, Dept Farmacol, Burjassot, Valencia, Spain
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Shen, YH,Weng, ZY,Zhao, QS,et al. Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme[J]. PLANTA MEDICA,2005,71(8):770-775.
APA Shen, YH.,Weng, ZY.,Zhao, QS.,Zeng, YQ.,Rios, J.,...&Sun, HD.(2005).Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme.PLANTA MEDICA,71(8),770-775.
MLA Shen, YH,et al."Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme".PLANTA MEDICA 71.8(2005):770-775.
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