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题名: Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme
作者: Shen, YH; Weng, ZY; null(赵勤实); Zeng, YQ; Rios, J; Xiao, WL; null(许刚); null(孙汉董)
刊名: PLANTA MEDICA
关键词: Lysimachia foenum-graecum ; saponin ; triterpene glycosides ; arachidonic acid
英文摘要: Five new oleanane-type triterpene saponins, named foenumosides A (1), B (2), C (3), D (4) and E (5), were isolated from the aerial parts of Lysimachia foenum-graecum Hance. Their structures were identified on the basis of 1D and 2D NMR techniques, including H-H COSY, HMQC, HMBC, HMQC-TOCSY, ROESY experiments as well as chemical methods. We have evaluated the cytotoxity of 1-5 against rat and human polymorphonuclear leukocytes and the effect of 5 on the arachidonic acid metabolizing enzyme. All compounds showed a high degree of toxicity except for compound 5, while 5 notably reduced the production of leukotriene B-4 (LTB4) from rat peritoneal leukocytes with an IC50 value of 74 mu M without inhibiting human elastase. Compound 5 also reduced the production of 12-HHTrE and 12-HETE by 14% and 50% as a measurement for cyclooxygenase-1 and 12-lipoxygenase inhibition at 100 mu M.
出版日期: 2005-08-01
卷号: 71, 期号:8, 页码:770-775
DOI标识: 10.1055/s-2005-871289
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15436
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kumming Inst Bot, Heilongtan 650204, Kuming, Peoples R China
2.Univ Valencia, Fac Farm, Dept Farmacol, Burjassot, Valencia, Spain
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Shen, YH; Weng, ZY; Zhao, QS; Zeng, YQ; Rios, J; Xiao, WL; Xu, G; Sun, HD.Five new triterpene glycosides from Lysimachia foenum-graecum and evaluation of their effect on the arachidonic acid metabolizing enzyme,PLANTA MEDICA,2005,71(8):770-775
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