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题名: Two new abietane diterpenoids from Salvia yunnanensis
作者: null(许刚); Peng, LY; Lu, L; Weng, ZY; Zhao, Y; Li, XL; null(赵勤实); null(孙汉董)
刊名: PLANTA MEDICA
关键词: MILTIORRHIZA ; TANSHINONES ; BUNGE
英文摘要: Two new abietane diterpenoids, yunnannin A (1) and danshenol C (2), were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A (3), przewalskin (4), tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds 1-3 were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound 3 showed inhibited growth of K562 (IC50 = 0.53 mu g/mL), T-24 (IC50 = 7.94 mu g/mL), QGY (IC50 = 4.65 mu g/mL) and Me180 (IC50 = 6.89 mu g/mL) cell lines while compound 2 was inactive. Compound 1 showed moderate inhibitory activity on QGY (IC50 = 16.75 mu g/mL) and Me180 (IC50 = 5.84 mu g/ mL) cells.
出版日期: 2006
卷号: 72, 期号:1, 页码:84-86
DOI标识: 10.1055/s-2005-873184
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15432
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Ints Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Guiyang Med Coll, Guiyang, Peoples R China

Recommended Citation:
Xu, G; Peng, LY; Lu, L; Weng, ZY; Zhao, Y; Li, XL; Zhao, QS; Sun, HD.Two new abietane diterpenoids from Salvia yunnanensis,PLANTA MEDICA,2006,72(1):84-86
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