中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Prediction of broad spectrum resistance of tumors towards anticancer drugs
作者: Efferth, Thomas ; Konkimalla, V. Badireenath ; null(王易芬) ; Sauerbrey, Axel ; Meinhardt, Silke ; Zintl, Felix ; Mattern, Juegen ; Volm, Manfred
刊名: CLINICAL CANCER RESEARCH
关键词: TRADITIONAL CHINESE MEDICINE ; CASSETTE TRANSPORTER GENES ; SHORT-TERM TEST ; MULTIDRUG-RESISTANCE ; CELL-LINES ; CANCER-CHEMOTHERAPY ; TETRAZOLIUM ASSAY ; SENSITIVITY ; LEUKEMIA ; CYTOTOXICITY
英文摘要: Purpose: Drug resistance is a major obstacle in cancer chemotherapy. Although the statistical probability of therapeutic success is known for larger patient groups from clinical therapy trials, it is difficult to predict the individual response of tumors. The concept of individualized therapy aims to determine in vitro the drug response of tumors beforehand to choose effective treatment options for each individual patient. Experimental Design: We analyzed the cross-resistance profiles of different tumor types (cancers of lung, breast, and colon, and leukemia) towards drugs from different classes (anthracyclines, antibiotics, Vinca alkaloids, epipodophyllotoxins, antimetabolites, and alkylating agents) by nucleotide incorporation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Hierarchical cluster analysis and COMPARE analyses were applied. Results: Tumors exert broad resistance profiles, e.g., tumors resistant to one drug tend to also be resistant to other drugs, whereas sensitive tumors reveal sensitivity towards many drugs. Interestingly, the broad spectrum resistance phenotype could reliably be predicted by doxorubicin alone. Expression of the ATP-binding cassette transporter P-glycoprotein (ABCB1, MDR1) and the proliferative activity of tumors were identified as underlying mechanisms of broad spectrum resistance. To find novel compounds with activity against drug-resistant tumors, a database with 2,420 natural products was screened for compounds acting independent of P-glycoprotein and the proliferative state of tumor cells. Conclusions: umors exert cross-resistance profiles much broader than the classical multidrug resistance phenotype. Broad spectrum resistance can be predicted by doxorubicin due to the multifactorial mode of action of this drug. Novel cytotoxic compunds from natural resources might be valuable tools for strategies to bypass broad spectrum resistance.
出版日期: 2008
卷号: 14, 期号:8, 页码:2405-2412
语种: 英语
收录类别: sci
学科分类: Oncology
ISSN号: 1078-0432
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15388
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2012101512.pdf(210KB)----开放获取--View Download

Recommended Citation:
Efferth, Thomas; Konkimalla, V. Badireenath; Wang, Yi-Fen; Sauerbrey, Axel; Meinhardt, Silke; Zintl, Felix; Mattern, Juegen; Volm, Manfred.Prediction of broad spectrum resistance of tumors towards anticancer drugs,CLINICAL CANCER RESEARCH,2008,14(8):2405-2412
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Efferth, Thomas]'s Articles
[Konkimalla, V. Badireenath]'s Articles
[Wang, Yi-Fen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Efferth, Thomas]‘s Articles
[Konkimalla, V. Badireenath]‘s Articles
[Wang, Yi-Fen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2012101512.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace