| Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release | |
Wanga, Junfeng1,2; Dong, Shasha1,4; Wang, Yuehu1 ; Lu, Qing1; Zhong, Huimin2; Du, Guanhua3; Zhang, Li3; Cheng, Yongxian1
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| 通讯作者 | Zhang, L (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Inst Bot, Lanhei Rd 134, Kunming 650204, Yunnan, Peoples R China. zhangli@imm.ac.cn ; yxcheng@mail.kib.ac.cn |
| 2008-09-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| ISSN | 0968-0896 |
| 卷号 | 16期号:18页码:8510-8515 |
| 摘要 | Investigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were established by detailed spectroscopic methods. The stereochemistry of compounds 1 and 2 were determined by single-crystal X-ray diffraction. In exception of compounds 2, 6 and 10, all the other compounds were examined for their inhibitory effects on nitric oxide production in lipopolysaccharides-activated macrophages. Compounds 1, 3, 7, 8 and 9 inhibited the release of nitric oxide with IC(50) values of 45.32, 63.51, 52.81, 30.19 and 46.18 mu M, respectively. Furthermore, compound 1 was found to inhibit the expression of inducible nitric oxide synthase. (C) 2008 Elsevier Ltd. All rights reserved. |
| 关键词 | Myrica Nana Cyclic Diarylheptanoids Myricananins A-e Nitric Oxide Release Inos |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| DOI | 10.1016/j.bmc.2008.08.020 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259173400022 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15380 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Shandong, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 4.Dali Univ, Coll Pharmaceut Sci, Dali 671002, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wanga, Junfeng,Dong, Shasha,Wang, Yuehu,et al. Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2008,16(18):8510-8515. |
| APA | Wanga, Junfeng.,Dong, Shasha.,Wang, Yuehu.,Lu, Qing.,Zhong, Huimin.,...&Cheng, Yongxian.(2008).Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release.BIOORGANIC & MEDICINAL CHEMISTRY,16(18),8510-8515. |
| MLA | Wanga, Junfeng,et al."Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release".BIOORGANIC & MEDICINAL CHEMISTRY 16.18(2008):8510-8515. |
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