Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release
Wanga, Junfeng1,2; Dong, Shasha1,4; Wang, Yuehu1; Lu, Qing1; Zhong, Huimin2; Du, Guanhua3; Zhang, Li3; Cheng, Yongxian1
Corresponding AuthorZhang, L (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Inst Bot, Lanhei Rd 134, Kunming 650204, Yunnan, Peoples R China. zhangli@imm.ac.cn ; yxcheng@mail.kib.ac.cn
2008-09-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
Volume16Issue:18Pages:8510-8515
AbstractInvestigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were established by detailed spectroscopic methods. The stereochemistry of compounds 1 and 2 were determined by single-crystal X-ray diffraction. In exception of compounds 2, 6 and 10, all the other compounds were examined for their inhibitory effects on nitric oxide production in lipopolysaccharides-activated macrophages. Compounds 1, 3, 7, 8 and 9 inhibited the release of nitric oxide with IC(50) values of 45.32, 63.51, 52.81, 30.19 and 46.18 mu M, respectively. Furthermore, compound 1 was found to inhibit the expression of inducible nitric oxide synthase. (C) 2008 Elsevier Ltd. All rights reserved.
KeywordMyrica Nana Cyclic Diarylheptanoids Myricananins A-e Nitric Oxide Release Inos
Subject AreaBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmc.2008.08.020
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000259173400022
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15380
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Shandong, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Dali Univ, Coll Pharmaceut Sci, Dali 671002, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wanga, Junfeng,Dong, Shasha,Wang, Yuehu,et al. Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2008,16(18):8510-8515.
APA Wanga, Junfeng.,Dong, Shasha.,Wang, Yuehu.,Lu, Qing.,Zhong, Huimin.,...&Cheng, Yongxian.(2008).Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release.BIOORGANIC & MEDICINAL CHEMISTRY,16(18),8510-8515.
MLA Wanga, Junfeng,et al."Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release".BIOORGANIC & MEDICINAL CHEMISTRY 16.18(2008):8510-8515.
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