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题名: Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release
作者: Wanga, Junfeng1, 2; Dong, Shasha1, 4; Wang, Yuehu1; Lu, Qing1; Zhong, Huimin2; Du, Guanhua3; Zhang, Li3; null(程永现)1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
关键词: Myrica nana ; cyclic diarylheptanoids ; myricananins A-E ; nitric oxide release ; iNOS
英文摘要: Investigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were established by detailed spectroscopic methods. The stereochemistry of compounds 1 and 2 were determined by single-crystal X-ray diffraction. In exception of compounds 2, 6 and 10, all the other compounds were examined for their inhibitory effects on nitric oxide production in lipopolysaccharides-activated macrophages. Compounds 1, 3, 7, 8 and 9 inhibited the release of nitric oxide with IC(50) values of 45.32, 63.51, 52.81, 30.19 and 46.18 mu M, respectively. Furthermore, compound 1 was found to inhibit the expression of inducible nitric oxide synthase. (C) 2008 Elsevier Ltd. All rights reserved.
出版日期: 2008-09-15
卷号: 16, 期号:18, 页码:8510-8515
DOI标识: 10.1016/j.bmc.2008.08.020
语种: 英语
ISSN号: 0968-0896
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15380
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Shandong, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Dali Univ, Coll Pharmaceut Sci, Dali 671002, Yunnan, Peoples R China

Recommended Citation:
Wanga, Junfeng; Dong, Shasha; Wang, Yuehu; Lu, Qing; Zhong, Huimin; Du, Guanhua; Zhang, Li; Cheng, Yongxian.Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release,BIOORGANIC & MEDICINAL CHEMISTRY,2008,16(18):8510-8515
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