Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells

	Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells
	Taechowisan, Thongchai ; Wanbanjob, Asawin ; Tuntiwachwuttikul, Pittaya ; Liu, Jikai
通讯作者	Taechowisan, T (reprint author), Silpakorn Univ, Dept Microbiol, Fac Sci, Nakhon Pathom 73000, Thailand. tthongch@su.ac.th
	2010
发表期刊	FOOD AND AGRICULTURAL IMMUNOLOGY
ISSN	0954-0105
卷号	21 期号:1 页码:57-64
摘要	In inflammation, proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we investigated the effects of lansai C and D on NO production in lipopolysaccharide-induced RAW 264.7 cells, and evaluated the mechanisms of action of the compounds. Lansai C and D inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner. These compounds inhibited the activation of nuclear factor-B, which is a significant transcription factor for iNOS and also inhibited the activation of the signal transducer and activator of transcription-1, another important transcription factor for iNOS. The present study characterises the effects and mechanisms of lansais on iNOS expression and NO production in activated macrophages. The results explain the pharmacological efficacy of lansais as anti-inflammatory compounds.
关键词	Anti-inflammatory Activity Lansai c And d Nf-kappa b Raw 264 7 Cells Stat-1 Nitric-oxide Synthase Streptomyces Sp Suc1 Selective-inhibition Inos Expression Macrophages Gamma
学科领域	Chemistry, Applied ; Food Science & Technology ; Immunology ; Toxicology
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/15376
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,et al. Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2010,21(1):57-64.
APA	Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,&Liu, Jikai.(2010).Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells.FOOD AND AGRICULTURAL IMMUNOLOGY,21(1),57-64.
MLA	Taechowisan, Thongchai,et al."Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells".FOOD AND AGRICULTURAL IMMUNOLOGY 21.1(2010):57-64.

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