Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells
Taechowisan, Thongchai ; Wanbanjob, Asawin ; Tuntiwachwuttikul, Pittaya ; Liu, Jikai
2010
发表期刊FOOD AND AGRICULTURAL IMMUNOLOGY
ISSN0954-0105
卷号21期号:1页码:57-64
摘要In inflammation, proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we investigated the effects of lansai C and D on NO production in lipopolysaccharide-induced RAW 264.7 cells, and evaluated the mechanisms of action of the compounds. Lansai C and D inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner. These compounds inhibited the activation of nuclear factor-B, which is a significant transcription factor for iNOS and also inhibited the activation of the signal transducer and activator of transcription-1, another important transcription factor for iNOS. The present study characterises the effects and mechanisms of lansais on iNOS expression and NO production in activated macrophages. The results explain the pharmacological efficacy of lansais as anti-inflammatory compounds.
关键词Anti-inflammatory Activity Lansai c And d Nf-kappa b Raw 264 7 Cells Stat-1 Nitric-oxide Synthase Streptomyces Sp Suc1 Selective-inhibition Inos Expression Macrophages Gamma
资助信息Thailand Research Fund[MRG5180173]; Faculty of Science, Silpakorn University
学科领域Chemistry, Applied ; Food Science & Technology ; Immunology ; Toxicology
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15376
专题植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,et al. Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2010,21(1):57-64.
APA Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,&Liu, Jikai.(2010).Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells.FOOD AND AGRICULTURAL IMMUNOLOGY,21(1),57-64.
MLA Taechowisan, Thongchai,et al."Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells".FOOD AND AGRICULTURAL IMMUNOLOGY 21.1(2010):57-64.
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