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题名: Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells
作者: Taechowisan, Thongchai ; Wanbanjob, Asawin ; Tuntiwachwuttikul, Pittaya ; Liu, Jikai
刊名: FOOD AND AGRICULTURAL IMMUNOLOGY
关键词: anti-inflammatory activity ; lansai C and D ; NF-kappa B ; RAW 264 ; 7 cells ; STAT-1 ; NITRIC-OXIDE SYNTHASE ; STREPTOMYCES SP SUC1 ; SELECTIVE-INHIBITION ; INOS EXPRESSION ; MACROPHAGES ; GAMMA
英文摘要: In inflammation, proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we investigated the effects of lansai C and D on NO production in lipopolysaccharide-induced RAW 264.7 cells, and evaluated the mechanisms of action of the compounds. Lansai C and D inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner. These compounds inhibited the activation of nuclear factor-B, which is a significant transcription factor for iNOS and also inhibited the activation of the signal transducer and activator of transcription-1, another important transcription factor for iNOS. The present study characterises the effects and mechanisms of lansais on iNOS expression and NO production in activated macrophages. The results explain the pharmacological efficacy of lansais as anti-inflammatory compounds.
出版日期: 2010
卷号: 21, 期号:1, 页码:57-64
语种: 英语
收录类别: sci
学科分类: Chemistry, Applied; Food Science & Technology; Immunology; Toxicology
ISSN号: 0954-0105
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15376
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Taechowisan, Thongchai; Wanbanjob, Asawin; Tuntiwachwuttikul, Pittaya; Liu, Jikai.Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells,FOOD AND AGRICULTURAL IMMUNOLOGY,2010,21(1):57-64
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