Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells
Taechowisan, Thongchai ; Wanbanjob, Asawin ; Tuntiwachwuttikul, Pittaya ; Liu, Jikai
Corresponding AuthorTaechowisan, T (reprint author), Silpakorn Univ, Dept Microbiol, Fac Sci, Nakhon Pathom 73000, Thailand. tthongch@su.ac.th
2010
Source PublicationFOOD AND AGRICULTURAL IMMUNOLOGY
ISSN0954-0105
Volume21Issue:1Pages:57-64
AbstractIn inflammation, proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we investigated the effects of lansai C and D on NO production in lipopolysaccharide-induced RAW 264.7 cells, and evaluated the mechanisms of action of the compounds. Lansai C and D inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner. These compounds inhibited the activation of nuclear factor-B, which is a significant transcription factor for iNOS and also inhibited the activation of the signal transducer and activator of transcription-1, another important transcription factor for iNOS. The present study characterises the effects and mechanisms of lansais on iNOS expression and NO production in activated macrophages. The results explain the pharmacological efficacy of lansais as anti-inflammatory compounds.
KeywordAnti-inflammatory Activity Lansai c And d Nf-kappa b Raw 264 7 Cells Stat-1 Nitric-oxide Synthase Streptomyces Sp Suc1 Selective-inhibition Inos Expression Macrophages Gamma
Subject AreaChemistry, Applied ; Food Science & Technology ; Immunology ; Toxicology
Indexed Bysci
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15376
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,et al. Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2010,21(1):57-64.
APA Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,&Liu, Jikai.(2010).Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells.FOOD AND AGRICULTURAL IMMUNOLOGY,21(1),57-64.
MLA Taechowisan, Thongchai,et al."Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-kappa B activations in LPS-induced RAW 264.7 cells".FOOD AND AGRICULTURAL IMMUNOLOGY 21.1(2010):57-64.
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