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题名: Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin
作者: Zhu, Qin-Chang1, 3; Wang, Yi1, 4; Liu, Ya-Ping2; Zhang, Rui-Qi1; Li, Xiang1; Su, Wen-Han1; Long, Fei1; null(罗晓东)2; Peng, Tao1, 4
刊名: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
关键词: Enterovirus ; Laggera pterodonta ; Flavonol ; Antiviral activity
英文摘要: In recent years, enterovirus 71 (EV71) infections have caused an increasing epidemic in young children, accompanying with more severe nervous system disease and more deaths. Unfortunately, there is no specific medication for it so far. Here we investigated the anti-EV71 activity of chrysosplenetin and penduletin, two o-methylated flavonols isolated from the leaves of Laggera pterodonta. These two compounds were found to have strong activity in vitro against EV71 with low cytotoxicity. In the cytopathic effect (CPE) inhibition assays, both plaque reduction assay and virus yield inhibition assay, the compounds showed a similar 50% inhibitory concentration (IC(50)) value of about 0.20 mu M. The selectivity indices (SI) of chrysosplenetin and penduletin were 107.5 and 655.6 in African green monkey kidney (Vero) cells, and 69.5 and 200.5 in human rhabdomyosarcoma (RD) cells, accordingly. The preliminary mechanism analysis indicates that they function not through blocking virus entry or inactivating virus directly but inhibiting viral RNA replication. In the time-of-addition assay, both compounds inhibited progeny virus production and RNA replication by nearly 100% when introduced within 4 h post infection. In addition to EV71, both compounds inhibited several other human enteroviruses with similar efficacy. These findings provide a significant lead for the discovery of anti-EV71 drug. (C) 2011 Elsevier B.V. All rights reserved.
出版日期: 2011-10-09
卷号: 44, 期号:3, 页码:392-398
DOI标识: 10.1016/j.ejps.2011.08.030
语种: 英语
ISSN号: 0928-0987
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15370
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Viral Immunol, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China
2.State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Nagasaki Univ, Sch Pharmaceut Sci, Lab Chem Biofunct Mol, Nagasaki 8528521, Japan
4.S China United Vaccine Inst, Guangzhou 510633, Guangdong, Peoples R China

Recommended Citation:
Zhu, Qin-Chang; Wang, Yi; Liu, Ya-Ping; Zhang, Rui-Qi; Li, Xiang; Su, Wen-Han; Long, Fei; Luo, Xiao-Dong; Peng, Tao.Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin,EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2011,44(3):392-398
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