毛萼乙素纳米混悬剂.Ⅱ.对小鼠肝癌H22移植瘤的生长抑制作用
王健 ; 侯惠民 ; 夏怡然 ; 孙汉董 ; 普建新
2012
Source Publication中国医药工业杂志
ISSN1001-8255
Issue3Pages:194-197
Contribution Rank第三
Abstract采用小鼠肝癌H22移植性肿瘤模型,考察不同给药途径和剂量下,毛萼乙素纳米混悬剂的抗肿瘤作用及毒性。在适宜的给药剂量下,毛萼乙素纳米混悬剂经静脉注射、腹腔注射和灌胃3种途径给药均可抑制小鼠肝癌H22移植瘤的生长,并呈现明确的量效关系,但其毒性也随着剂量的增加而明显增大。在10 mg/kg的剂量下,腹腔注射的抑瘤作用优于静脉注射;但该途径给药产生的毒性也比静脉注射大。灌胃给药的抑瘤作用最弱,且高剂量时会产生严重的胃肠道不良反应。
Keyword毛萼乙素 纳米混悬剂 生长抑制作用 药效 毒性
Indexed Bycscd
Language中文
CSCD IDCSCD:4519801
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15202
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
王健,侯惠民,夏怡然,等. 毛萼乙素纳米混悬剂.Ⅱ.对小鼠肝癌H22移植瘤的生长抑制作用[J]. 中国医药工业杂志,2012(3):194-197.
APA 王健,侯惠民,夏怡然,孙汉董,&普建新.(2012).毛萼乙素纳米混悬剂.Ⅱ.对小鼠肝癌H22移植瘤的生长抑制作用.中国医药工业杂志(3),194-197.
MLA 王健,et al."毛萼乙素纳米混悬剂.Ⅱ.对小鼠肝癌H22移植瘤的生长抑制作用".中国医药工业杂志 .3(2012):194-197.
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