Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum
Zhao Qing1; Zou Cheng2; Yu Qin2; Zhao Sheng-Ding1; He Hong-Ping3; Hao Xiao-Jiang3
2012-06-10
发表期刊CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
卷号33期号:6页码:1220-1225
摘要Research on active components from rhizomes of Hedychium genus has led to isolation of some diterpenes with significant cytotoxic activities against Chinese hamster V-79 cells, KB cells, K562 cells, A549 cells, etc.. Hedychium villosum Wall. is a perennial rhizomatous herb distributed in China and partially in Southeast Asia, which is used in the treatment of pain and inflammation. A new labdane-type diterpene(1), together with a known one(3), were isolated from Hedychiurn villosum. The new diterpene was named as villosumcoronarin, which partially isomerized to its epimer 1' in solution, e. g., chloroform or methanol. The gross structures of compounds 1 and 1' were elucidated on the basis of MS, ER, H-1 NMR, C-13-DEPT NMR, H-1-H-1 COSY and HMBC. The relative configuration was determined by H-1 NMR, ROESY and computational methods. Compound 1 was identified as (11S, 15R)-11-hydroxy-8(17), 12(E)-labdadien-15,16-dial 11,15-hemiacetal. The known compound 3 was oxidized by Jones reagent to get diterpene derivative 4. Bioassays revealed that compound 1 had strong cytotoxic activity against HL-60 and SMMC-7721 cells with IC50 values of 0.74 and 4.48 mu mol/L, respectively, the activities were stronger than the positive control, cis-diaminedichloroplatinum(DDP). Compound 4 also showed significant activities against HL-60 and SMMC-7721 cells with IC50 values of 3.15 and 9.57 mmol/L, respectively.
关键词Hedychium Villosum Diterpene Cytotoxic Activity
学科领域Chemistry, Multidisciplinary
DOI10.3969/j.issn.0251-0790.2012.06.017
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000305819100017
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15093
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ Tradit Chinese Med, Sch Chinese Mat Med, Kunming 650500, Peoples R China
2.Kunming Med Univ, Coll Pharmaceut Sci, Kunming 650500, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
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Zhao Qing,Zou Cheng,Yu Qin,et al. Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2012,33(6):1220-1225.
APA Zhao Qing,Zou Cheng,Yu Qin,Zhao Sheng-Ding,He Hong-Ping,&Hao Xiao-Jiang.(2012).Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,33(6),1220-1225.
MLA Zhao Qing,et al."Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 33.6(2012):1220-1225.
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