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题名: Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum
作者: Zhao Qing1; Zou Cheng2; Yu Qin2; Zhao Sheng-Ding1; He Hong-Ping3; Hao Xiao-Jiang3
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
关键词: Hedychium villosum ; Diterpene ; Cytotoxic activity
英文摘要: Research on active components from rhizomes of Hedychium genus has led to isolation of some diterpenes with significant cytotoxic activities against Chinese hamster V-79 cells, KB cells, K562 cells, A549 cells, etc.. Hedychium villosum Wall. is a perennial rhizomatous herb distributed in China and partially in Southeast Asia, which is used in the treatment of pain and inflammation. A new labdane-type diterpene(1), together with a known one(3), were isolated from Hedychiurn villosum. The new diterpene was named as villosumcoronarin, which partially isomerized to its epimer 1' in solution, e. g., chloroform or methanol. The gross structures of compounds 1 and 1' were elucidated on the basis of MS, ER, H-1 NMR, C-13-DEPT NMR, H-1-H-1 COSY and HMBC. The relative configuration was determined by H-1 NMR, ROESY and computational methods. Compound 1 was identified as (11S, 15R)-11-hydroxy-8(17), 12(E)-labdadien-15,16-dial 11,15-hemiacetal. The known compound 3 was oxidized by Jones reagent to get diterpene derivative 4. Bioassays revealed that compound 1 had strong cytotoxic activity against HL-60 and SMMC-7721 cells with IC50 values of 0.74 and 4.48 mu mol/L, respectively, the activities were stronger than the positive control, cis-diaminedichloroplatinum(DDP). Compound 4 also showed significant activities against HL-60 and SMMC-7721 cells with IC50 values of 3.15 and 9.57 mmol/L, respectively.
出版日期: 2012-06-10
卷号: 33, 期号:6, 页码:1220-1225
DOI标识: 10.3969/j.issn.0251-0790.2012.06.017
语种: 英语
ISSN号: 0251-0790
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15093
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ Tradit Chinese Med, Sch Chinese Mat Med, Kunming 650500, Peoples R China
2.Kunming Med Univ, Coll Pharmaceut Sci, Kunming 650500, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Zhao Qing; Zou Cheng; Yu Qin; Zhao Sheng-Ding; He Hong-Ping; Hao Xiao-Jiang.Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum,CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2012,33(6):1220-1225
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