| Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia | |
Nian, Yin1,2 ; Wang, Hai-Yan1,2; Su, Jia1,2; Zhou, Lin1; Feng, Gang1; Li, Yan1; Qiu, Ming-Hua1
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| Corresponding Author | Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn |
| 2012-08-12 | |
| Source Publication | TETRAHEDRON
 |
| ISSN | 0040-4020 |
| Volume | 68Issue:32Pages:6521-6527 |
| Abstract | Phytochemical investigation on the roots of Cimicifuga heracleifolia afforded nine new 9,19-cycloartane triterpenes (1-9), along with seven known constituents (10-16). The new structures were elucidated by spectroscopic and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that eight cimigenol-type compounds (1-3,5, 10-12,14) showed different levels of cytotoxic activities, with IC50 values ranging from 0.83 to 23.94 mu M. In addition, their structural and bioactive features enriched the structure-activity relationships we proposed before. (C) 2012 Elsevier Ltd. All rights reserved. |
| Keyword | Cimicifuga Heracleifolia Cycloartane Triterpenes Cytotoxicity Structure-activity Relationships |
| Subject Area | Chemistry, Organic |
| DOI | 10.1016/j.tet.2012.05.083 |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS ID | WOS:000306267800017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/15081 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Nian, Yin,Wang, Hai-Yan,Su, Jia,et al. Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia[J]. TETRAHEDRON,2012,68(32):6521-6527. |
| APA | Nian, Yin.,Wang, Hai-Yan.,Su, Jia.,Zhou, Lin.,Feng, Gang.,...&Qiu, Ming-Hua.(2012).Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia.TETRAHEDRON,68(32),6521-6527. |
| MLA | Nian, Yin,et al."Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia".TETRAHEDRON 68.32(2012):6521-6527. |
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