Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia
Nian, Yin1,2; Wang, Hai-Yan1,2; Su, Jia1,2; Zhou, Lin1; Feng, Gang1; Li, Yan1; Qiu, Ming-Hua1
2012-08-12
发表期刊TETRAHEDRON
ISSN0040-4020
卷号68期号:32页码:6521-6527
摘要Phytochemical investigation on the roots of Cimicifuga heracleifolia afforded nine new 9,19-cycloartane triterpenes (1-9), along with seven known constituents (10-16). The new structures were elucidated by spectroscopic and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that eight cimigenol-type compounds (1-3,5, 10-12,14) showed different levels of cytotoxic activities, with IC50 values ranging from 0.83 to 23.94 mu M. In addition, their structural and bioactive features enriched the structure-activity relationships we proposed before. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Cimicifuga Heracleifolia Cycloartane Triterpenes Cytotoxicity Structure-activity Relationships
资助信息National Natural Science Foundation of China[U1132604]; Knowledge Innovation Program of the CAS[KZCX2-XB2-15-03, KSCX2-EW-R-15]; top talents program of Yunnan province[2009C1120]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ14]
学科领域Chemistry, Organic
DOI10.1016/j.tet.2012.05.083
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000306267800017
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15081
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Nian, Yin,Wang, Hai-Yan,Su, Jia,et al. Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia[J]. TETRAHEDRON,2012,68(32):6521-6527.
APA Nian, Yin.,Wang, Hai-Yan.,Su, Jia.,Zhou, Lin.,Feng, Gang.,...&Qiu, Ming-Hua.(2012).Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia.TETRAHEDRON,68(32),6521-6527.
MLA Nian, Yin,et al."Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia".TETRAHEDRON 68.32(2012):6521-6527.
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