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题名: Triterpenes from Isodon xerophilus
作者: Li Li-Mei1; Pu Jian-Xin2; Xiao Wei-Lie2; null(孙汉董)2
刊名: CHINESE JOURNAL OF NATURAL MEDICINES
关键词: Isodon xerophilus ; Labiatae ; Triterpenes ; Biosynthetic pathway ; Cytotoxicity
英文摘要: AIM: To investigate the chemical constituents of Isodon xerophilus. METHODS: The constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analyses. Their cytotoxicity was evaluated by the MTT method in 96-well microplates. RESULTS: Ten triterpenes were isolated and identified as oleanolic acid (1), ursolic acid (2), maslinic acid (3), 2 alpha-hydroxyursolic acid (4), hederagenin (5), 3 beta, 23-dihydroxy-urs-12-en-28-oic acid (6), arjunolic acid (7), asiatic acid (8), 2 alpha, 3 alpha, 24-trihydroxyolean-12-en-28-oic acid (9), and 2 alpha, 3 alpha, 24-trihydroxyurs-12-en-28-oic acid (10). All compounds were tested against three human tumor cell lines, K562, MKN45, and HepG2. CONCLUSION: All of the compounds were isolated from this plant for the first time. The proposed biosynthetic pathway of these triterpenes was discussed. All of the triterpenes showed noncytotoxic activity against the above-mentioned three human tumor cell lines.
出版日期: 2012-07-01
卷号: 10, 期号:4, 页码:307-310
DOI标识: 10.3724/SP.J.1009.2012.00307
语种: 英语
收录类别: SCI
学科分类: Integrative & Complementary Medicine; Pharmacology & Pharmacy ; Integrative & Complementary Medicine; Pharmacology & Pharmacy
ISSN号: 1672-3651 ; 1672-3651
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15079
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

Recommended Citation:
Li Li-Mei; Pu Jian-Xin; Xiao Wei-Lie; Sun Han-Dong.Triterpenes from Isodon xerophilus,CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(4):307-310
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