| Triterpenes from Isodon xerophilus | |
Li Li-Mei1; Pu Jian-Xin2 ; Xiao Wei-Lie2; Sun Han-Dong2
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| 通讯作者 | Li, LM (reprint author), Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China. ; Li, LM (reprint author), Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China. ; limeiligy@gmail.com ; limeiligy@gmail.com |
| 2012-07-01 | |
| 发表期刊 | CHINESE JOURNAL OF NATURAL MEDICINES
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| ISSN | 1672-3651 ; 1672-3651 |
| 卷号 | 10期号:4页码:307-310 |
| 摘要 | AIM: To investigate the chemical constituents of Isodon xerophilus. METHODS: The constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analyses. Their cytotoxicity was evaluated by the MTT method in 96-well microplates. RESULTS: Ten triterpenes were isolated and identified as oleanolic acid (1), ursolic acid (2), maslinic acid (3), 2 alpha-hydroxyursolic acid (4), hederagenin (5), 3 beta, 23-dihydroxy-urs-12-en-28-oic acid (6), arjunolic acid (7), asiatic acid (8), 2 alpha, 3 alpha, 24-trihydroxyolean-12-en-28-oic acid (9), and 2 alpha, 3 alpha, 24-trihydroxyurs-12-en-28-oic acid (10). All compounds were tested against three human tumor cell lines, K562, MKN45, and HepG2. CONCLUSION: All of the compounds were isolated from this plant for the first time. The proposed biosynthetic pathway of these triterpenes was discussed. All of the triterpenes showed noncytotoxic activity against the above-mentioned three human tumor cell lines. |
| 关键词 | Isodon Xerophilus Labiatae Triterpenes Biosynthetic Pathway Cytotoxicity |
| 学科领域 | Integrative & Complementary Medicine ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy ; Pharmacology & Pharmacy |
| DOI | 10.3724/SP.J.1009.2012.00307 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306300200015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15079 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Li-Mei,Pu Jian-Xin,Xiao Wei-Lie,et al. Triterpenes from Isodon xerophilus[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(4):307-310. |
| APA | Li Li-Mei,Pu Jian-Xin,Xiao Wei-Lie,&Sun Han-Dong.(2012).Triterpenes from Isodon xerophilus.CHINESE JOURNAL OF NATURAL MEDICINES,10(4),307-310. |
| MLA | Li Li-Mei,et al."Triterpenes from Isodon xerophilus".CHINESE JOURNAL OF NATURAL MEDICINES 10.4(2012):307-310. |
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