Triterpenes from Isodon xerophilus
Li Li-Mei1; Pu Jian-Xin2; Xiao Wei-Lie2; Sun Han-Dong2
通讯作者Li, LM (reprint author), Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China. ; Li, LM (reprint author), Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China. ; limeiligy@gmail.com ; limeiligy@gmail.com
2012-07-01
发表期刊CHINESE JOURNAL OF NATURAL MEDICINES
ISSN1672-3651 ; 1672-3651
卷号10期号:4页码:307-310
摘要AIM: To investigate the chemical constituents of Isodon xerophilus. METHODS: The constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analyses. Their cytotoxicity was evaluated by the MTT method in 96-well microplates. RESULTS: Ten triterpenes were isolated and identified as oleanolic acid (1), ursolic acid (2), maslinic acid (3), 2 alpha-hydroxyursolic acid (4), hederagenin (5), 3 beta, 23-dihydroxy-urs-12-en-28-oic acid (6), arjunolic acid (7), asiatic acid (8), 2 alpha, 3 alpha, 24-trihydroxyolean-12-en-28-oic acid (9), and 2 alpha, 3 alpha, 24-trihydroxyurs-12-en-28-oic acid (10). All compounds were tested against three human tumor cell lines, K562, MKN45, and HepG2. CONCLUSION: All of the compounds were isolated from this plant for the first time. The proposed biosynthetic pathway of these triterpenes was discussed. All of the triterpenes showed noncytotoxic activity against the above-mentioned three human tumor cell lines.
关键词Isodon Xerophilus Labiatae Triterpenes Biosynthetic Pathway Cytotoxicity
学科领域Integrative & Complementary Medicine ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy ; Pharmacology & Pharmacy
DOI10.3724/SP.J.1009.2012.00307
收录类别SCI
语种英语
WOS记录号WOS:000306300200015
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15079
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Li Li-Mei,Pu Jian-Xin,Xiao Wei-Lie,et al. Triterpenes from Isodon xerophilus[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(4):307-310.
APA Li Li-Mei,Pu Jian-Xin,Xiao Wei-Lie,&Sun Han-Dong.(2012).Triterpenes from Isodon xerophilus.CHINESE JOURNAL OF NATURAL MEDICINES,10(4),307-310.
MLA Li Li-Mei,et al."Triterpenes from Isodon xerophilus".CHINESE JOURNAL OF NATURAL MEDICINES 10.4(2012):307-310.
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