Triterpenes from Isodon xerophilus
Li Li-Mei1; Pu Jian-Xin2; Xiao Wei-Lie2; Sun Han-Dong2
2012-07-01
发表期刊CHINESE JOURNAL OF NATURAL MEDICINES
ISSN1672-3651 ; 1672-3651
卷号10期号:4页码:307-310
摘要AIM: To investigate the chemical constituents of Isodon xerophilus. METHODS: The constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analyses. Their cytotoxicity was evaluated by the MTT method in 96-well microplates. RESULTS: Ten triterpenes were isolated and identified as oleanolic acid (1), ursolic acid (2), maslinic acid (3), 2 alpha-hydroxyursolic acid (4), hederagenin (5), 3 beta, 23-dihydroxy-urs-12-en-28-oic acid (6), arjunolic acid (7), asiatic acid (8), 2 alpha, 3 alpha, 24-trihydroxyolean-12-en-28-oic acid (9), and 2 alpha, 3 alpha, 24-trihydroxyurs-12-en-28-oic acid (10). All compounds were tested against three human tumor cell lines, K562, MKN45, and HepG2. CONCLUSION: All of the compounds were isolated from this plant for the first time. The proposed biosynthetic pathway of these triterpenes was discussed. All of the triterpenes showed noncytotoxic activity against the above-mentioned three human tumor cell lines.
关键词Isodon Xerophilus Labiatae Triterpenes Biosynthetic Pathway Cytotoxicity
资助信息National Natural Science Foundation of China[21172024]; Chinese Ministry of Education[212151]; NSFC-Joint Foundation of Yunnan Province[U0832602]; Major State Basic Research Development Program of China[2009CB522300, 2009CB940900]; Science and Technology Program of Yunnan Province[2008IF010, 2008CD162]; Major Direction Projection Foundation of CAS[2010KIBA05]; National Natural Science Foundation of China[21172024]; Chinese Ministry of Education[212151]; NSFC-Joint Foundation of Yunnan Province[U0832602]; Major State Basic Research Development Program of China[2009CB522300, 2009CB940900]; Science and Technology Program of Yunnan Province[2008IF010, 2008CD162]; Major Direction Projection Foundation of CAS[2010KIBA05]
学科领域Integrative & Complementary Medicine ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy ; Pharmacology & Pharmacy
DOI10.3724/SP.J.1009.2012.00307
收录类别SCI
语种英语
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS类目Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:000306300200015
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15079
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chengdu Med Coll, Res Ctr, Chengdu 610083, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714
Li Li-Mei,Pu Jian-Xin,Xiao Wei-Lie,et al. Triterpenes from Isodon xerophilus[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(4):307-310.
APA Li Li-Mei,Pu Jian-Xin,Xiao Wei-Lie,&Sun Han-Dong.(2012).Triterpenes from Isodon xerophilus.CHINESE JOURNAL OF NATURAL MEDICINES,10(4),307-310.
MLA Li Li-Mei,et al."Triterpenes from Isodon xerophilus".CHINESE JOURNAL OF NATURAL MEDICINES 10.4(2012):307-310.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201209030003.pdf(510KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li Li-Mei]的文章
[Pu Jian-Xin]的文章
[Xiao Wei-Lie]的文章
百度学术
百度学术中相似的文章
[Li Li-Mei]的文章
[Pu Jian-Xin]的文章
[Xiao Wei-Lie]的文章
必应学术
必应学术中相似的文章
[Li Li-Mei]的文章
[Pu Jian-Xin]的文章
[Xiao Wei-Lie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。