Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa
Zhang, Li1; Cheng, Yong-Xian2; Liu, Ai-Lin1; Wang, Hai-Di1; Wang, Ya-Ling2; Du, Guan-Hua1
2010-11-01
发表期刊MOLECULES
ISSN1420-3049
卷号15期号:11页码:8507-8517
摘要The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mu g/mL and 1.27 mu g/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC50 values of 3.82 mu g/mL and 1.90 mu g/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-alpha by 22.73%, 33.14% and 37.19% at 5 mu g/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.
关键词Chaenomeles Speciosa Antioxidants Anti-inflammatory Na Inhibition
资助信息Ministry of Science and Technology of China [2009ZX09302-003, 2009ZX09102-123, 2008ZX09401-004]; MOE ; MOHRSS ; Talent Scholarship of Yunnan Youth [2007PY01-48]
学科领域Chemistry ; Organic
DOI10.3390/molecules15118507
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000284582100070
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1501
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,et al. Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa[J]. MOLECULES,2010,15(11):8507-8517.
APA Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,Wang, Hai-Di,Wang, Ya-Ling,&Du, Guan-Hua.(2010).Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa.MOLECULES,15(11),8507-8517.
MLA Zhang, Li,et al."Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa".MOLECULES 15.11(2010):8507-8517.
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