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题名: Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa
作者: Zhang, Li1; null(程永现)2; Liu, Ai-Lin1; Wang, Hai-Di1; Wang, Ya-Ling2; Du, Guan-Hua1
刊名: MOLECULES
关键词: Chaenomeles speciosa ; antioxidants ; anti-inflammatory ; NA inhibition
英文摘要: The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mu g/mL and 1.27 mu g/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC50 values of 3.82 mu g/mL and 1.90 mu g/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-alpha by 22.73%, 33.14% and 37.19% at 5 mu g/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.
出版日期: 2010-11-01
卷号: 15, 期号:11, 页码:8507-8517
DOI标识: 10.3390/molecules15118507
语种: 英语
收录类别: SCI
学科分类: Chemistry ; Organic
ISSN号: 1420-3049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1501
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

Recommended Citation:
Zhang, L; Cheng, YX; Liu, AL; Wang, HD; Wang, YL; Du, GH.Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa,MOLECULES,2010,15(11):8507-8517
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