Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa
Zhang, Li1; Cheng, Yong-Xian2; Liu, Ai-Lin1; Wang, Hai-Di1; Wang, Ya-Ling2; Du, Guan-Hua1
2010-11-01
Source PublicationMOLECULES
ISSN1420-3049
Volume15Issue:11Pages:8507-8517
AbstractThe fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates. The results showed that 3,4-dihydroxybenzoic acid (1) displayed higher inhibitory activities on DPPH and NA with IC(50) values of 1.02 mu g/mL and 1.27 mu g/mL respectively, and quercetin (2) also showed significant inhibitory action on DPPH and NA, with IC50 values of 3.82 mu g/mL and 1.90 mu g/mL. Compounds 1, 2 and methyl 3-hydroxybutanedioic ester (3) could inhibit the production of TNF-alpha by 22.73%, 33.14% and 37.19% at 5 mu g/mL (P < 0.05) compared with the control. In addition, compound 2 was found to be active on the release of IL-6 in RAW264.7 macrophage cells, with an inhibitory rate of 39.79% (P < 0.05). The anti-inflammatory effect of compound 3 is disclosed for the first time in this study. Avian influenza is usually accompanied by virus invasion followed by the occurrence of oxidative stress and serious inflammation, so the multiple effects of the isolates may play a cocktail-like role in the treatment of avian influenza, and C. speciosa components, especially quercetin, might be a potent source for anti-viral and anti-inflammatory agents.
KeywordChaenomeles Speciosa Antioxidants Anti-inflammatory Na Inhibition
Subject AreaChemistry ; Organic
DOI10.3390/molecules15118507
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000284582100070
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1501
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,et al. Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa[J]. MOLECULES,2010,15(11):8507-8517.
APA Zhang, Li,Cheng, Yong-Xian,Liu, Ai-Lin,Wang, Hai-Di,Wang, Ya-Ling,&Du, Guan-Hua.(2010).Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa.MOLECULES,15(11),8507-8517.
MLA Zhang, Li,et al."Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa".MOLECULES 15.11(2010):8507-8517.
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