Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis

doi:10.1016/j.jep.2005.11.008

	Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis
	Wang, RR ; Gu, QO ; Yang, LM ; Chen, JJ; Li, SY ; Zheng, YT
	2006-04-21
发表期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
卷号	105 期号:1-2 页码:269-273
摘要	Rhus chinensis, a species used in folk medicine by Chinese native people, the anti-HIV-1 activities of the petroleum ether, ethyl acetate, butanol and aqueous extract of Rhus chinensis, named as RC-1, RC-2, RC-3 and RC-4, respectively, was evaluated. The petroleum ether extract RC-1 can inhibit the syncytium formation and HIV-1 p24 antigen at non-cytotoxic concentrations, the 50% effective concentration (EC50) were 0.71 and 0.93 mu g/ml, respectively. The therapeutic index (TI) was about 100. RC-1 had no activity on inhibiting HIV-1 recombinant RT and RIV-1 entry into host cells. Results showed that RC-1 was effective against HIV-1 and Rhus chinensis would be a useful medicinal plant for the chemotherapy of HIV-1 infection. RC-1 might inhibit the post steps or target the new sites of HIV-1 replication. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
关键词	Rhus Chinensis Hiv-1 Anti-hiv Activity Botanicals
学科领域	Plant Sciences ; Chemistry ; Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI	10.1016/j.jep.2005.11.008
收录类别	SCI
语种	英语
WOS记录号	WOS:000237101300039
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1477
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Kunming Med Coll, Fac Pharmaceut Sci, Kunming 650031, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang, RR,Gu, QO,Yang, LM,et al. Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):269-273.
APA	Wang, RR,Gu, QO,Yang, LM,Chen, JJ,Li, SY,&Zheng, YT.(2006).Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis.JOURNAL OF ETHNOPHARMACOLOGY,105(1-2),269-273.
MLA	Wang, RR,et al."Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis".JOURNAL OF ETHNOPHARMACOLOGY 105.1-2(2006):269-273.

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