Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis
Wang, RR; Gu, QO; Yang, LM; Chen, JJ; Li, SY; Zheng, YT
2006-04-21
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
Volume105Issue:1-2Pages:269-273
AbstractRhus chinensis, a species used in folk medicine by Chinese native people, the anti-HIV-1 activities of the petroleum ether, ethyl acetate, butanol and aqueous extract of Rhus chinensis, named as RC-1, RC-2, RC-3 and RC-4, respectively, was evaluated. The petroleum ether extract RC-1 can inhibit the syncytium formation and HIV-1 p24 antigen at non-cytotoxic concentrations, the 50% effective concentration (EC50) were 0.71 and 0.93 mu g/ml, respectively. The therapeutic index (TI) was about 100. RC-1 had no activity on inhibiting HIV-1 recombinant RT and RIV-1 entry into host cells. Results showed that RC-1 was effective against HIV-1 and Rhus chinensis would be a useful medicinal plant for the chemotherapy of HIV-1 infection. RC-1 might inhibit the post steps or target the new sites of HIV-1 replication. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
KeywordRhus Chinensis Hiv-1 Anti-hiv Activity Botanicals
Subject AreaPlant Sciences ; Chemistry ; Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.1016/j.jep.2005.11.008
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000237101300039
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1477
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Kunming Med Coll, Fac Pharmaceut Sci, Kunming 650031, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang, RR,Gu, QO,Yang, LM,et al. Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):269-273.
APA Wang, RR,Gu, QO,Yang, LM,Chen, JJ,Li, SY,&Zheng, YT.(2006).Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis.JOURNAL OF ETHNOPHARMACOLOGY,105(1-2),269-273.
MLA Wang, RR,et al."Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis".JOURNAL OF ETHNOPHARMACOLOGY 105.1-2(2006):269-273.
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