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题名: Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis
作者: Wang, RR; Gu, QO; Yang, LM; null(陈纪军); Li, SY; Zheng, YT
刊名: JOURNAL OF ETHNOPHARMACOLOGY
关键词: Rhus chinensis ; HIV-1 ; anti-HIV activity ; botanicals
英文摘要: Rhus chinensis, a species used in folk medicine by Chinese native people, the anti-HIV-1 activities of the petroleum ether, ethyl acetate, butanol and aqueous extract of Rhus chinensis, named as RC-1, RC-2, RC-3 and RC-4, respectively, was evaluated. The petroleum ether extract RC-1 can inhibit the syncytium formation and HIV-1 p24 antigen at non-cytotoxic concentrations, the 50% effective concentration (EC50) were 0.71 and 0.93 mu g/ml, respectively. The therapeutic index (TI) was about 100. RC-1 had no activity on inhibiting HIV-1 recombinant RT and RIV-1 entry into host cells. Results showed that RC-1 was effective against HIV-1 and Rhus chinensis would be a useful medicinal plant for the chemotherapy of HIV-1 infection. RC-1 might inhibit the post steps or target the new sites of HIV-1 replication. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
出版日期: 2006-04-21
卷号: 105, 期号:1-2, 页码:269-273
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry; Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
ISSN号: 0378-8741
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1477
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Kunming Med Coll, Fac Pharmaceut Sci, Kunming 650031, Yunnan, Peoples R China

Recommended Citation:
Wang, RR; Gu, QO; Yang, LM; Chen, JJ; Li, SY; Zheng, YT.Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis,JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):269-273
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