中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica
作者: Li, L; Shen, YM; Yang, XS; Zuo, GY; Shen, ZQ; Chen, ZH; null(郝小江)
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
关键词: atisine-type diterpene alkaloid ; platelet aggregation ; arachidonic acid ; adenosine-5 '-diphosphate ; PAF (platelet-activating factor) ; structure-activity relationship
英文摘要: Six diterpene alkaloids with an atisine-type C-20-skeleton isolated from the Chinese herbal medicines Spiraea japonica var. acuta and S. japonica var. ovalifolia, as well as eight derivatives of spiramine C and spiradine F were evaluated for the ability to inhibit aggregation of rabbit platelets induced by arachidonic acid, ADP, and platelet-activating factor (PAF) in vitro. The results showed that 12 of the 14 atisine-type diterpene alkaloids significantly inhibited PAF-induced platelet aggregation in a concentration-dependent manner, but had no effect on ADP- or arachidonic acid-induced aggregation, exhibiting a selective inhibition. It is the first report that C-20-diterpene alkaloids inhibit PAF-induced platelet aggregation. However, spiramine C1 concentration-dependently inhibited platelet aggregation induced by PAF, ADP and arachidonic acid with IC50 values of 30.5 +/- 2.7, 56.8 +/- 8.4 and 29.9 +/- 9.9 muM, respectively, suggesting a non-selective antiplatelet aggregation action. The inhibitory effect of spiramine C1 on arachidonic acid was as potent as that of aspirin. Primary studies of the structure-activity relationships for inhibition of PAF-induced aggregation showed that the oxygen substitution at the C-15 position and the presence of an oxazolidine ring in spiramine alkaloids were essential to their antiplatelet aggregation effects. These results suggest that the atisine-type alkaloids isolated from S. japonica are a class of novel antiplatelet aggregation agents. (C) 2002 Elsevier Science B.V All rights reserved.
出版日期: 2002-08-02
卷号: 449, 期号:1-2, 页码:23-28
语种: 英语
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14627
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2012091121.pdf(203KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Yunnan, Peoples R China
3.Key Lab Chem Nat Prod Guizhou Province, Guiyang 550002, Guizhou, Peoples R China
4.Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China

Recommended Citation:
Li, L; Shen, YM; Yang, XS; Zuo, GY; Shen, ZQ; Chen, ZH; Hao, XJ.Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica,EUROPEAN JOURNAL OF PHARMACOLOGY,2002,449(1-2):23-28
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, L]'s Articles
[Shen, YM]'s Articles
[Yang, XS]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, L]‘s Articles
[Shen, YM]‘s Articles
[Yang, XS]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2012091121.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace