Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora
Niu, XM; Li, SH; Li, ML; Zhao, QS; Mei, SX; Na, Z; Wang, SJ; Lin, ZW; Sun, HD
2002-06-01
Source PublicationPLANTA MEDICA
Volume68Issue:6Pages:528-533
AbstractThree new ent-kaurane diterpenoids laxiflorin E (1), laxiflorin H (6) and laxiflorin I (8) were isolated from the leaves of Isodon eriocalyx var. laxiflora, along with nine known diterpenoids, eriocalyxin A (2), laxiflorin C (3), laxiflorin D (4), laxiflorin A (5), maoecrystal S (7), maoecrystal Q (9), eriocalyxin B (10), maoecrystal C (11) and enmelol (12). The structures of the new compounds were determined by spectroscopic methods. Compounds 1-5 are 6,7-seco-ent-kaurane-7,20-olide diterpenoids, and 6-12 belong to 7,20-epoxy-ent-kauranoids. The spectral data of enmelol (12) are reported here for the first time. Ten of these compounds were tested for their cytotoxicity toward K562 and T24 human tumor cells. Compounds 1, 3 and 10 showed significant inhibitory effects on K562 cells with IC50 values 0.077, 0.569 and 0.373 mug/mL, and compounds 1 and 10 also demonstrated significant inhibitory activities toward T24 cells with IC50 values 0.709 and 0.087 mug/mL. Compounds 8 and 11 also displayed inhibitory effect on both two kinds of cells with IC50 value less than 6.5 mug/mL.
KeywordIsodon Eriocalyx Var. Laxiflora Labiatae Laxiflorins e And H-i Ent-kauranoids Cytotoxicity
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000176898700011
Citation statistics
Cited Times:57[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/14587
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Niu, XM,Li, SH,Li, ML,et al. Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora[J]. PLANTA MEDICA,2002,68(6):528-533.
APA Niu, XM.,Li, SH.,Li, ML.,Zhao, QS.,Mei, SX.,...&Sun, HD.(2002).Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora.PLANTA MEDICA,68(6),528-533.
MLA Niu, XM,et al."Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora".PLANTA MEDICA 68.6(2002):528-533.
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