Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora

	Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora
	Niu, XM ; Li, SH; Li, ML ; Zhao, QS; Mei, SX ; Na, Z ; Wang, SJ ; Lin, ZW ; Sun, HD
	2002-06-01
发表期刊	PLANTA MEDICA
卷号	68 期号:6 页码:528-533
摘要	Three new ent-kaurane diterpenoids laxiflorin E (1), laxiflorin H (6) and laxiflorin I (8) were isolated from the leaves of Isodon eriocalyx var. laxiflora, along with nine known diterpenoids, eriocalyxin A (2), laxiflorin C (3), laxiflorin D (4), laxiflorin A (5), maoecrystal S (7), maoecrystal Q (9), eriocalyxin B (10), maoecrystal C (11) and enmelol (12). The structures of the new compounds were determined by spectroscopic methods. Compounds 1-5 are 6,7-seco-ent-kaurane-7,20-olide diterpenoids, and 6-12 belong to 7,20-epoxy-ent-kauranoids. The spectral data of enmelol (12) are reported here for the first time. Ten of these compounds were tested for their cytotoxicity toward K562 and T24 human tumor cells. Compounds 1, 3 and 10 showed significant inhibitory effects on K562 cells with IC50 values 0.077, 0.569 and 0.373 mug/mL, and compounds 1 and 10 also demonstrated significant inhibitory activities toward T24 cells with IC50 values 0.709 and 0.087 mug/mL. Compounds 8 and 11 also displayed inhibitory effect on both two kinds of cells with IC50 value less than 6.5 mug/mL.
关键词	Isodon Eriocalyx Var. Laxiflora Labiatae Laxiflorins e And H-i Ent-kauranoids Cytotoxicity
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000176898700011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/14587
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Niu, XM,Li, SH,Li, ML,et al. Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora[J]. PLANTA MEDICA,2002,68(6):528-533.
APA	Niu, XM.,Li, SH.,Li, ML.,Zhao, QS.,Mei, SX.,...&Sun, HD.(2002).Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora.PLANTA MEDICA,68(6),528-533.
MLA	Niu, XM,et al."Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora".PLANTA MEDICA 68.6(2002):528-533.

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