Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora
Niu, XM; Li, SH; Li, ML; Zhao, QS; Mei, SX; Na, Z; Wang, SJ; Lin, ZW; Sun, HD
2002-06-01
发表期刊PLANTA MEDICA
卷号68期号:6页码:528-533
摘要Three new ent-kaurane diterpenoids laxiflorin E (1), laxiflorin H (6) and laxiflorin I (8) were isolated from the leaves of Isodon eriocalyx var. laxiflora, along with nine known diterpenoids, eriocalyxin A (2), laxiflorin C (3), laxiflorin D (4), laxiflorin A (5), maoecrystal S (7), maoecrystal Q (9), eriocalyxin B (10), maoecrystal C (11) and enmelol (12). The structures of the new compounds were determined by spectroscopic methods. Compounds 1-5 are 6,7-seco-ent-kaurane-7,20-olide diterpenoids, and 6-12 belong to 7,20-epoxy-ent-kauranoids. The spectral data of enmelol (12) are reported here for the first time. Ten of these compounds were tested for their cytotoxicity toward K562 and T24 human tumor cells. Compounds 1, 3 and 10 showed significant inhibitory effects on K562 cells with IC50 values 0.077, 0.569 and 0.373 mug/mL, and compounds 1 and 10 also demonstrated significant inhibitory activities toward T24 cells with IC50 values 0.709 and 0.087 mug/mL. Compounds 8 and 11 also displayed inhibitory effect on both two kinds of cells with IC50 value less than 6.5 mug/mL.
关键词Isodon Eriocalyx Var. Laxiflora Labiatae Laxiflorins e And H-i Ent-kauranoids Cytotoxicity
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000176898700011
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被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14587
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
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Niu, XM,Li, SH,Li, ML,et al. Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora[J]. PLANTA MEDICA,2002,68(6):528-533.
APA Niu, XM.,Li, SH.,Li, ML.,Zhao, QS.,Mei, SX.,...&Sun, HD.(2002).Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora.PLANTA MEDICA,68(6),528-533.
MLA Niu, XM,et al."Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora".PLANTA MEDICA 68.6(2002):528-533.
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