Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata

	Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata
	Jiang, B ; Hou, AJ ; Li, ML ; Li, SH; Han, QB ; Wang, SJ ; Lin, ZW ; Sun, HD
	2002-10-01
发表期刊	PLANTA MEDICA
卷号	68 期号:10 页码:921-925
摘要	Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodo-sin (6), epi-nodosinol (7), enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some di-terpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC50 values ranging from 3.2 mug/ml to 8.2 mug/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.
关键词	Isodon Sculponeata Labiatae Diterpenoids Sculponeatins F-i Cytotoxicity
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000178977000012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/14585
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China 3.Dali Med Coll, Dept Pharmaceut, Dali, Peoples R China
推荐引用方式 GB/T 7714	Jiang, B,Hou, AJ,Li, ML,et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata[J]. PLANTA MEDICA,2002,68(10):921-925.
APA	Jiang, B.,Hou, AJ.,Li, ML.,Li, SH.,Han, QB.,...&Sun, HD.(2002).Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata.PLANTA MEDICA,68(10),921-925.
MLA	Jiang, B,et al."Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata".PLANTA MEDICA 68.10(2002):921-925.

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