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题名: Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata
作者: Jiang, B; Hou, AJ; Li, ML; null(黎胜红); Han, QB; Wang, SJ; Lin, ZW; null(孙汉董)
刊名: PLANTA MEDICA
关键词: Isodon sculponeata ; Labiatae ; diterpenoids ; sculponeatins F-I ; cytotoxicity
英文摘要: Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodo-sin (6), epi-nodosinol (7), enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some di-terpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC50 values ranging from 3.2 mug/ml to 8.2 mug/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.
出版日期: 2002-10-01
卷号: 68, 期号:10, 页码:921-925
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14585
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
3.Dali Med Coll, Dept Pharmaceut, Dali, Peoples R China

Recommended Citation:
Jiang, B; Hou, AJ; Li, ML; Li, SH; Han, QB; Wang, SJ; Lin, ZW; Sun, HD.Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata,PLANTA MEDICA,2002,68(10):921-925
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