Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata
Jiang, B; Hou, AJ; Li, ML; Li, SH; Han, QB; Wang, SJ; Lin, ZW; Sun, HD
2002-10-01
发表期刊PLANTA MEDICA
卷号68期号:10页码:921-925
摘要Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodo-sin (6), epi-nodosinol (7), enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some di-terpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC50 values ranging from 3.2 mug/ml to 8.2 mug/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.
关键词Isodon Sculponeata Labiatae Diterpenoids Sculponeatins F-i Cytotoxicity
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14585
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
3.Dali Med Coll, Dept Pharmaceut, Dali, Peoples R China
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Jiang, B,Hou, AJ,Li, ML,et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata[J]. PLANTA MEDICA,2002,68(10):921-925.
APA Jiang, B.,Hou, AJ.,Li, ML.,Li, SH.,Han, QB.,...&Sun, HD.(2002).Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata.PLANTA MEDICA,68(10),921-925.
MLA Jiang, B,et al."Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata".PLANTA MEDICA 68.10(2002):921-925.
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