| Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica | |
| Tang, Jun2,3; Wang, Conan K.1; Pan, Xulin2; Yan, He2,3; Zeng, Guangzhi2; Xu, Wenyan2,3; He, Wenjun2,3; Daly, Norelle L.1; Craik, David J.1; Tan, Ninghua2 | |
| 2010 | |
| 发表期刊 | HELVETICA CHIMICA ACTA
 |
| 卷号 | 93期号:11页码:2287-2295 |
| 摘要 | Many Violaceae plants contain cyclotides, which are plant cyclopeptides distinguished by a cyclic cystine knot motif with 28-37 amino acid residues. In the current study, four new cyclotides, vila A - D (1-4 resp), together with a known cyclotide, vary D (5), were isolated from Viola labridorica (Violaceae) A chromatography-based method was used to isolate the cyclotides, which were characterized using tandem mass spectrometry and 2D-NMR spectroscopy Several of the cyclotides showed cytotoxic activities against five cancer cell lines, i e, U251 MDA-MB-231, A549 DU145, and BEL-7402, with vila A and B (1 and 2, resp) being the most cytotoxic The isolated cyclotides showed no antibacterial activity against Staphyloccocus aureus and Candida albicans Homology modeling of the cyclotide structures was used to analyze structure-activity relationships. |
| 学科领域 | Chemistry, Multidisciplinary |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000285069500023 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/14515 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Jun,Wang, Conan K.,Pan, Xulin,et al. Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica[J]. HELVETICA CHIMICA ACTA,2010,93(11):2287-2295. |
| APA | Tang, Jun.,Wang, Conan K..,Pan, Xulin.,Yan, He.,Zeng, Guangzhi.,...&Tan, Ninghua.(2010).Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica.HELVETICA CHIMICA ACTA,93(11),2287-2295. |
| MLA | Tang, Jun,et al."Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica".HELVETICA CHIMICA ACTA 93.11(2010):2287-2295. |
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