Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica
Tang, Jun2,3; Wang, Conan K.1; Pan, Xulin2; Yan, He2,3; Zeng, Guangzhi2; Xu, Wenyan2,3; He, Wenjun2,3; Daly, Norelle L.1; Craik, David J.1; Tan, Ninghua2
2010
发表期刊HELVETICA CHIMICA ACTA
卷号93期号:11页码:2287-2295
摘要Many Violaceae plants contain cyclotides, which are plant cyclopeptides distinguished by a cyclic cystine knot motif with 28-37 amino acid residues. In the current study, four new cyclotides, vila A - D (1-4 resp), together with a known cyclotide, vary D (5), were isolated from Viola labridorica (Violaceae) A chromatography-based method was used to isolate the cyclotides, which were characterized using tandem mass spectrometry and 2D-NMR spectroscopy Several of the cyclotides showed cytotoxic activities against five cancer cell lines, i e, U251 MDA-MB-231, A549 DU145, and BEL-7402, with vila A and B (1 and 2, resp) being the most cytotoxic The isolated cyclotides showed no antibacterial activity against Staphyloccocus aureus and Candida albicans Homology modeling of the cyclotide structures was used to analyze structure-activity relationships.
学科领域Chemistry, Multidisciplinary
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000285069500023
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14515
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Tang, Jun,Wang, Conan K.,Pan, Xulin,et al. Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica[J]. HELVETICA CHIMICA ACTA,2010,93(11):2287-2295.
APA Tang, Jun.,Wang, Conan K..,Pan, Xulin.,Yan, He.,Zeng, Guangzhi.,...&Tan, Ninghua.(2010).Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica.HELVETICA CHIMICA ACTA,93(11),2287-2295.
MLA Tang, Jun,et al."Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica".HELVETICA CHIMICA ACTA 93.11(2010):2287-2295.
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