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题名: Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica
作者: Tang, Jun2, 3; Wang, Conan K.1; Pan, Xulin2; Yan, He2, 3; Zeng, Guangzhi2; Xu, Wenyan2, 3; He, Wenjun2, 3; Daly, Norelle L.1; Craik, David J.1; Tan, Ninghua2
刊名: HELVETICA CHIMICA ACTA
英文摘要: Many Violaceae plants contain cyclotides, which are plant cyclopeptides distinguished by a cyclic cystine knot motif with 28-37 amino acid residues. In the current study, four new cyclotides, vila A - D (1-4 resp), together with a known cyclotide, vary D (5), were isolated from Viola labridorica (Violaceae) A chromatography-based method was used to isolate the cyclotides, which were characterized using tandem mass spectrometry and 2D-NMR spectroscopy Several of the cyclotides showed cytotoxic activities against five cancer cell lines, i e, U251 MDA-MB-231, A549 DU145, and BEL-7402, with vila A and B (1 and 2, resp) being the most cytotoxic The isolated cyclotides showed no antibacterial activity against Staphyloccocus aureus and Candida albicans Homology modeling of the cyclotide structures was used to analyze structure-activity relationships.
出版日期: 2010
卷号: 93, 期号:11, 页码:2287-2295
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14515
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Tang, J; Wang, CK; Pan, XL; Yan, H; Zeng, GZ; Xu, WY; He, WJ; Daly, NL; Craik, DJ; Tan, NH.Isolation and Characterization of Bioactive Cyclotides from Viola labrilorica,HELVETICA CHIMICA ACTA,2010,93(11):2287-2295
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