Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds

	Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds
	Chen, Gang 1; He, Hong-ping 2; Ding, Jiang 3; Hao, Xiao-jiang2
	2009
发表期刊	HETEROCYCLIC COMMUNICATIONS
卷号	15 期号:5 页码:355-360
摘要	A series of spiro [pyrrolidine-2,3'-oxindole] derivatives were synthesized by 1,3-dipolar cycloaddition reaction of isatin, alpha-amino acid and (E)-beta-substituted-styrene. Four kinds of trapping dipolarophiles were introduced into this reaction, and the regioselectivity of these reactions proved to be the same fashion. Bioactivity screening showed these compounds were active on anti-tumor in A549 and P388 cell line, and several compounds were found to be active under the condensation of 10(-4)M.
学科领域	Chemistry, Organic
收录类别	SCI
语种	英语
WOS记录号	WOS:000275814300008
引用统计	被引频次：43[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/14507
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Gang,He, Hong-ping,Ding, Jiang,et al. Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds[J]. HETEROCYCLIC COMMUNICATIONS,2009,15(5):355-360.
APA	Chen, Gang,He, Hong-ping,Ding, Jiang,&Hao, Xiao-jiang.(2009).Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds.HETEROCYCLIC COMMUNICATIONS,15(5),355-360.
MLA	Chen, Gang,et al."Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds".HETEROCYCLIC COMMUNICATIONS 15.5(2009):355-360.

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