Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds | |
Chen, Gang1; He, Hong-ping2; Ding, Jiang3; Hao, Xiao-jiang2![]() | |
2009 | |
发表期刊 | HETEROCYCLIC COMMUNICATIONS
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卷号 | 15期号:5页码:355-360 |
摘要 | A series of spiro [pyrrolidine-2,3'-oxindole] derivatives were synthesized by 1,3-dipolar cycloaddition reaction of isatin, alpha-amino acid and (E)-beta-substituted-styrene. Four kinds of trapping dipolarophiles were introduced into this reaction, and the regioselectivity of these reactions proved to be the same fashion. Bioactivity screening showed these compounds were active on anti-tumor in A549 and P388 cell line, and several compounds were found to be active under the condensation of 10(-4)M. |
学科领域 | Chemistry, Organic |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000275814300008 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/14507 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Gang,He, Hong-ping,Ding, Jiang,et al. Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds[J]. HETEROCYCLIC COMMUNICATIONS,2009,15(5):355-360. |
APA | Chen, Gang,He, Hong-ping,Ding, Jiang,&Hao, Xiao-jiang.(2009).Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds.HETEROCYCLIC COMMUNICATIONS,15(5),355-360. |
MLA | Chen, Gang,et al."Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds".HETEROCYCLIC COMMUNICATIONS 15.5(2009):355-360. |
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