Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds
Chen, Gang1; He, Hong-ping2; Ding, Jiang3; Hao, Xiao-jiang2
2009
Source PublicationHETEROCYCLIC COMMUNICATIONS
Volume15Issue:5Pages:355-360
AbstractA series of spiro [pyrrolidine-2,3'-oxindole] derivatives were synthesized by 1,3-dipolar cycloaddition reaction of isatin, alpha-amino acid and (E)-beta-substituted-styrene. Four kinds of trapping dipolarophiles were introduced into this reaction, and the regioselectivity of these reactions proved to be the same fashion. Bioactivity screening showed these compounds were active on anti-tumor in A549 and P388 cell line, and several compounds were found to be active under the condensation of 10(-4)M.
Subject AreaChemistry, Organic
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000275814300008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/14507
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Chen, Gang,He, Hong-ping,Ding, Jiang,et al. Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds[J]. HETEROCYCLIC COMMUNICATIONS,2009,15(5):355-360.
APA Chen, Gang,He, Hong-ping,Ding, Jiang,&Hao, Xiao-jiang.(2009).Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds.HETEROCYCLIC COMMUNICATIONS,15(5),355-360.
MLA Chen, Gang,et al."Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds".HETEROCYCLIC COMMUNICATIONS 15.5(2009):355-360.
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