Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds
Chen, Gang1; He, Hong-ping2; Ding, Jiang3; Hao, Xiao-jiang2
2009
发表期刊HETEROCYCLIC COMMUNICATIONS
卷号15期号:5页码:355-360
摘要A series of spiro [pyrrolidine-2,3'-oxindole] derivatives were synthesized by 1,3-dipolar cycloaddition reaction of isatin, alpha-amino acid and (E)-beta-substituted-styrene. Four kinds of trapping dipolarophiles were introduced into this reaction, and the regioselectivity of these reactions proved to be the same fashion. Bioactivity screening showed these compounds were active on anti-tumor in A549 and P388 cell line, and several compounds were found to be active under the condensation of 10(-4)M.
学科领域Chemistry, Organic
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000275814300008
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14507
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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Chen, Gang,He, Hong-ping,Ding, Jiang,et al. Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds[J]. HETEROCYCLIC COMMUNICATIONS,2009,15(5):355-360.
APA Chen, Gang,He, Hong-ping,Ding, Jiang,&Hao, Xiao-jiang.(2009).Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds.HETEROCYCLIC COMMUNICATIONS,15(5),355-360.
MLA Chen, Gang,et al."Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3 '-oxindole] Compounds".HETEROCYCLIC COMMUNICATIONS 15.5(2009):355-360.
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