|摘要||Twelve 6, 7-seco-7, 20-olide-ent-kaurane diterpenoids, including seven new compounds named guidongnins B similar to H (1 similar to 7) and five known ones identified as ludongnin A (8), ludongnin B (9), guidongnin (10), angustifolin (11) and 6-epiangustifolin (12), were isolated from Isodon rubescens collected in Guizhou Province. On the basis of spectroscopic evidences, the new compounds were elucidated as 16 ( R)-methyl-6, 7-seco-6, 19; 7, 20-diolide-ent-kaur-15-one (1), 16 (R)-methyl-11alpha-hydroxy-6, 7-seco-6, 19; 7,20-diolide-ent-kaur-15-one (2), 16 (S)-hydroxymethyl-11alpha-hydroxy-6,7-seco-6,19;7,20-diolide-ent-kaur-15-one (3), 16(R)-methyl-6alpha-hydroxy-6, 7-seco-6,19-epoxy-7, 20-olide-ent-kaur-15-one (4), 16 (R)-methyl-6beta-hydroxy-6, 7-seco-6, 19-epoxy-7,20-olideent-kaur-15-one (5), 6beta,15beta-dihydroxy-6,7-seco-6,19-epoxy-7,20-olide-enx-kaur-16-ene (6) and 16(R)-methyl-19beta-oxymethyl-6,7-seco-6,19-epoxy-7,20-olide-ent-kaur-15-one (7), respectively. The structure of ludongnin B was revised by 2D-NMR spectra and the name of guidongnin (10) was renamed guidongnin A (10).|
Han, QB,Zhao, QS,Li, SH,et al. ent-kaurane diterpenoids from Isodon rubescens collected in Guizhou Province[J]. ACTA CHIMICA SINICA,2003,61(7):1077-1082.
Han, QB,Zhao, QS,Li, SH,Peng, LY,&Sun, HD.(2003).ent-kaurane diterpenoids from Isodon rubescens collected in Guizhou Province.ACTA CHIMICA SINICA,61(7),1077-1082.