Michael Addition between Isatin and Acrylate Derivatives
Chen, Gang1; Tang, Ying1; Zhang, Jie1; Wu, Ya1; Hao, Xiao-Jiang2; Mu, Shu-Zhen3,4
Corresponding AuthorChen, G (reprint author), Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China
2011-11-01
Source PublicationLETTERS IN ORGANIC CHEMISTRY
ISSN1570-1786
Volume8Issue:9Pages:614-617
AbstractA simple and efficient Michael addition of isatin to acrylate in the presence of KOH was described. Methyl beta-(2,3-dioxoindolin-1-yl) propanoate was synthesized firstly by the addition of isatin to methyl acrylate in a feasible approach using 10% KOH as catalyst in DMF with the highest yield of 72.5% under the optimized conditions. A series of beta-(2,3-dioxoindolin-1-yl) propanoate derivatives was synthesized according to this approach and gave moderate to relative high yields. The directive distinct color changes in this reaction were illuminated by the reaction mechanism analysis.
KeywordAcrylate Isatin Beta-(2 Michael Addition 3-dioxoindolin-1-yl) Propanoate
Subject AreaChemistry
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000299570700002
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/14485
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
4.Chinese Acad Sci, Guiyang 550002, Peoples R China
Recommended Citation
GB/T 7714
Chen, Gang,Tang, Ying,Zhang, Jie,et al. Michael Addition between Isatin and Acrylate Derivatives[J]. LETTERS IN ORGANIC CHEMISTRY,2011,8(9):614-617.
APA Chen, Gang,Tang, Ying,Zhang, Jie,Wu, Ya,Hao, Xiao-Jiang,&Mu, Shu-Zhen.(2011).Michael Addition between Isatin and Acrylate Derivatives.LETTERS IN ORGANIC CHEMISTRY,8(9),614-617.
MLA Chen, Gang,et al."Michael Addition between Isatin and Acrylate Derivatives".LETTERS IN ORGANIC CHEMISTRY 8.9(2011):614-617.
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