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题名: A New Chromene Isolated from Ageratum conyzoides
作者: Adebayo, Abiodun Humphrey1, 2; Ji, Chang-Jiu1; Zhang, Yu-Mei1; He, Wen-Jun1; Zeng, Guang-Zhi1; Han, Hong-Jin1; Xu, Jun-Ju1; Akindahunsi, Afolabi Akintunde3; Tan, Ning-Hua1
刊名: NATURAL PRODUCT COMMUNICATIONS
关键词: Ageratum conyzoides ; Compositae ; 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside ; cytotoxicity
英文摘要: From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3',5'-Tri-O-methyltricetin (7), precocene 11(9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC(50) values of 12.8, 24.8, 3.5 and 7.8 mu M respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC(50) value of 61 mu M; the others showed no significant cytotoxic activity on the cell lines tested.
出版日期: 2011-09-01
卷号: 6, 期号:9, 页码:1263-1265
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy; Food Science & Technology
ISSN号: 1934-578X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14479
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria
3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria

Recommended Citation:
Adebayo, AH; Ji, CJ; Zhang, YM; He, WJ; Zeng, GZ; Han, HJ; Xu, JJ; Akindahunsi, AA; Tan, NH.A New Chromene Isolated from Ageratum conyzoides,NATURAL PRODUCT COMMUNICATIONS,2011,6(9):1263-1265
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