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题名: Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole
作者: Chen, Wen1, 2, 3; Yang, Xiao-Dong1; null(李艳)4; Yang, Li-Juan2, 3; Wang, Xue-Quan1; Zhang, Gao-Lan1; Zhang, Hong-Bin1
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
关键词: BIOLOGICAL EVALUATION ; ANTITUMOR-ACTIVITY ; DERIVATIVES ; IODIDES ; ANALOGS ; LIGNANS ; TRANS ; DNA
英文摘要: A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.
出版日期: 2011
卷号: 9, 期号:11, 页码:4250-4255
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry
ISSN号: 1477-0520
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14477
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
2.Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
3.Yunnan Univ Nationalities, Sch Chem & Biotechnol, Minist Educ, Kunming 650031, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Chen, W; Yang, XD; Li, Y; Yang, LJ; Wang, XQ; Zhang, GL; Zhang, HB.Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole,ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(11):4250-4255
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