Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole

doi:10.1039/c1ob05116d

	Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole
	Chen, Wen 1,2,3; Yang, Xiao-Dong 1; Li, Yan4 ; Yang, Li-Juan 2,3; Wang, Xue-Quan 1; Zhang, Gao-Lan 1; Zhang, Hong-Bin 1
通讯作者	Zhang, HB (reprint author), Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
	2011
发表期刊	ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN	1477-0520
卷号	9 期号:11 页码:4250-4255
摘要	A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.
关键词	Biological Evaluation Antitumor-activity Derivatives Iodides Analogs Lignans Trans Dna
学科领域	Chemistry
DOI	10.1039/c1ob05116d
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000290735300037
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/14477
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China 2.Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China 3.Yunnan Univ Nationalities, Sch Chem & Biotechnol, Minist Educ, Kunming 650031, Peoples R China 4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Chen, Wen,Yang, Xiao-Dong,Li, Yan,et al. Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(11):4250-4255.
APA	Chen, Wen.,Yang, Xiao-Dong.,Li, Yan.,Yang, Li-Juan.,Wang, Xue-Quan.,...&Zhang, Hong-Bin.(2011).Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole.ORGANIC & BIOMOLECULAR CHEMISTRY,9(11),4250-4255.
MLA	Chen, Wen,et al."Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole".ORGANIC & BIOMOLECULAR CHEMISTRY 9.11(2011):4250-4255.

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