Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole
Chen, Wen1,2,3; Yang, Xiao-Dong1; Li, Yan4; Yang, Li-Juan2,3; Wang, Xue-Quan1; Zhang, Gao-Lan1; Zhang, Hong-Bin1
2011
发表期刊ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0520
卷号9期号:11页码:4250-4255
摘要A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.
关键词Biological Evaluation Antitumor-activity Derivatives Iodides Analogs Lignans Trans Dna
资助信息National Natural Science Foundation of China[30960460, 20925205, 20832005]; National Basic Research Program of China (973 Program)[2009CB522300]
学科领域Chemistry
DOI10.1039/c1ob05116d
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000290735300037
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14477
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
2.Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
3.Yunnan Univ Nationalities, Sch Chem & Biotechnol, Minist Educ, Kunming 650031, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
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Chen, Wen,Yang, Xiao-Dong,Li, Yan,et al. Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(11):4250-4255.
APA Chen, Wen.,Yang, Xiao-Dong.,Li, Yan.,Yang, Li-Juan.,Wang, Xue-Quan.,...&Zhang, Hong-Bin.(2011).Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole.ORGANIC & BIOMOLECULAR CHEMISTRY,9(11),4250-4255.
MLA Chen, Wen,et al."Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole".ORGANIC & BIOMOLECULAR CHEMISTRY 9.11(2011):4250-4255.
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