Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)
Adebayo, A. H.1,2; Tan, N. H.1; Akindahunsi, A. A.3; Zeng, G. Z.1; Zhang, Y. M.1
2010
发表期刊PHARMACOGNOSY MAGAZINE
卷号6期号:21页码:62-66
摘要Ageratum conyzoides has been used in folklore for the treatment of a wide range of diseases. In the present investigation, the in vitro activity of ethanol, petroleum ether, ethylacetate, butanol, and water extracts of A. conyzoides were screened in some cancer cell lines using the sulphorhodamine B (SRB) assay. These cell lines include: Human non-small cell lung carcinoma (A-549), human colon adenocarcinoma (HT-29), human gastric carcinoma (SGC-7901), human golima (U-251), human breast carcinoma (MDA-MB-231), human prostate carcinoma (DU-145), human hepatic carcinoma (BEL-7402), and mouse leukemia (P-388) cancer cell lines. Furthermore, kaempferol was isolated from the ethylacetate extract and the structure was elucidated by nuclear magnetic resonance (NMR) and mass spectroscopy. The effect of DPPH antiradical activity on the extracts and kaempferol was also determined. The results showed that ethylacetate extract exhibited the highest cytotoxic activity on A-549 and P-388 cancer cells with IC(50) values of 0.68 and 0.0003 mu g/ml, respectively. Kaempferol isolated from the ethylacetate extract of A. conyzoides rapidly scavenged DPPH at a concentration of 130.07 +/- 17.36 g/kg. The result therefore showed that A. conyzoides possessed anticancer and antiradical properties.
关键词Ageratum Conyzoides Anticancer Antiradical Scavenging Activity Cytotoxicity
学科领域Chemistry, Medicinal
DOI10.4103/0973-1296.59968
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000276883000011
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14471
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria
3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria
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Adebayo, A. H.,Tan, N. H.,Akindahunsi, A. A.,et al. Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)[J]. PHARMACOGNOSY MAGAZINE,2010,6(21):62-66.
APA Adebayo, A. H.,Tan, N. H.,Akindahunsi, A. A.,Zeng, G. Z.,&Zhang, Y. M..(2010).Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae).PHARMACOGNOSY MAGAZINE,6(21),62-66.
MLA Adebayo, A. H.,et al."Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)".PHARMACOGNOSY MAGAZINE 6.21(2010):62-66.
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