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题名: Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)
作者: Adebayo, A. H.1, 2; Tan, N. H.1; Akindahunsi, A. A.3; Zeng, G. Z.1; Zhang, Y. M.1
刊名: PHARMACOGNOSY MAGAZINE
关键词: Ageratum conyzoides ; anticancer ; antiradical scavenging activity ; cytotoxicity
英文摘要: Ageratum conyzoides has been used in folklore for the treatment of a wide range of diseases. In the present investigation, the in vitro activity of ethanol, petroleum ether, ethylacetate, butanol, and water extracts of A. conyzoides were screened in some cancer cell lines using the sulphorhodamine B (SRB) assay. These cell lines include: Human non-small cell lung carcinoma (A-549), human colon adenocarcinoma (HT-29), human gastric carcinoma (SGC-7901), human golima (U-251), human breast carcinoma (MDA-MB-231), human prostate carcinoma (DU-145), human hepatic carcinoma (BEL-7402), and mouse leukemia (P-388) cancer cell lines. Furthermore, kaempferol was isolated from the ethylacetate extract and the structure was elucidated by nuclear magnetic resonance (NMR) and mass spectroscopy. The effect of DPPH antiradical activity on the extracts and kaempferol was also determined. The results showed that ethylacetate extract exhibited the highest cytotoxic activity on A-549 and P-388 cancer cells with IC(50) values of 0.68 and 0.0003 mu g/ml, respectively. Kaempferol isolated from the ethylacetate extract of A. conyzoides rapidly scavenged DPPH at a concentration of 130.07 +/- 17.36 g/kg. The result therefore showed that A. conyzoides possessed anticancer and antiradical properties.
出版日期: 2010
卷号: 6, 期号:21, 页码:62-66
DOI标识: 10.4103/0973-1296.59968
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14471
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria
3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria

Recommended Citation:
Adebayo, A. H.,Tan, N. H.,Akindahunsi, A. A.,et al. Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)[J]. PHARMACOGNOSY MAGAZINE,2010,6(21):62-66.
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