| Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response | |
Wu, Gui-Sheng2 ; Luo, Huai-Rong2; Dong, Chuanhui3,4; Mastronardi, Claudio1; Licinio, Julio1; Wong, Ma-Li1
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| 通讯作者 | Wong, ML (reprint author), Australian Natl Univ, John Curtin Sch Med Res, Bldg 131,Garran Rd, Canberra, ACT 2601, Australia |
| 2011-02-01 | |
| 发表期刊 | PSYCHIATRIC GENETICS
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| ISSN | 0955-8829 |
| 卷号 | 21期号:1页码:14-18 |
| 摘要 | Objective Melanocortin 1 receptor (MC1R) is involved in various functions, such as pigmentation, antipyretic and anti-inflammatory actions, development of melanoma, susceptibility to ultraviolet-induced sun damage, modification of oculocutaneous albinism, development of freckles, and mediation of female-specific mechanisms of analgesia. MC1R's natural agonists include a-melanocyte-stimulating hormone and corticotrophin (ACTH1-39), which are important components of hypothalamic pituitary adrenal axis and increase in response to stress. Given the multiple relevant roles of MC1R, we studied whether the MC1R gene would be associated with susceptibility to major depressive disorder or with response to antidepressant treatment. |
| 关键词 | Antidepressant Association Haplotype Major Depression Melanocortin 1 Receptor Single Nucleotide Polymorphisms |
| 学科领域 | Genetics & Heredity ; Neurosciences & Neurology |
| DOI | 10.1097/YPG.0b013e32834133d2 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285544800003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/14467 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Ctr Drug Screening & Res, Beijing 100864, Yunnan, Peoples R China 3.Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA 4.Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA |
| 推荐引用方式 GB/T 7714 | Wu, Gui-Sheng,Luo, Huai-Rong,Dong, Chuanhui,et al. Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response[J]. PSYCHIATRIC GENETICS,2011,21(1):14-18. |
| APA | Wu, Gui-Sheng,Luo, Huai-Rong,Dong, Chuanhui,Mastronardi, Claudio,Licinio, Julio,&Wong, Ma-Li.(2011).Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response.PSYCHIATRIC GENETICS,21(1),14-18. |
| MLA | Wu, Gui-Sheng,et al."Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response".PSYCHIATRIC GENETICS 21.1(2011):14-18. |
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