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题名: Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response
作者: Wu, Gui-Sheng2; null(罗怀容)2; Dong, Chuanhui3, 4; Mastronardi, Claudio1; Licinio, Julio1; Wong, Ma-Li1
刊名: PSYCHIATRIC GENETICS
关键词: antidepressant ; association ; haplotype ; major depression ; melanocortin 1 receptor ; single nucleotide polymorphisms
英文摘要: Objective Melanocortin 1 receptor (MC1R) is involved in various functions, such as pigmentation, antipyretic and anti-inflammatory actions, development of melanoma, susceptibility to ultraviolet-induced sun damage, modification of oculocutaneous albinism, development of freckles, and mediation of female-specific mechanisms of analgesia. MC1R's natural agonists include a-melanocyte-stimulating hormone and corticotrophin (ACTH1-39), which are important components of hypothalamic pituitary adrenal axis and increase in response to stress. Given the multiple relevant roles of MC1R, we studied whether the MC1R gene would be associated with susceptibility to major depressive disorder or with response to antidepressant treatment.
出版日期: 2011-02-01
卷号: 21, 期号:1, 页码:14-18
DOI标识: 10.1097/YPG.0b013e32834133d2
语种: 英语
ISSN号: 0955-8829
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14467
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Ctr Drug Screening & Res, Beijing 100864, Yunnan, Peoples R China
3.Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA
4.Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA

Recommended Citation:
Wu, GS; Luo, HR; Dong, CH; Mastronardi, C; Licinio, J; Wong, ML.Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response,PSYCHIATRIC GENETICS,2011,21(1):14-18
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