Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response
Wu, Gui-Sheng2; Luo, Huai-Rong2; Dong, Chuanhui3,4; Mastronardi, Claudio1; Licinio, Julio1; Wong, Ma-Li1
2011-02-01
发表期刊PSYCHIATRIC GENETICS
ISSN0955-8829
卷号21期号:1页码:14-18
摘要Objective Melanocortin 1 receptor (MC1R) is involved in various functions, such as pigmentation, antipyretic and anti-inflammatory actions, development of melanoma, susceptibility to ultraviolet-induced sun damage, modification of oculocutaneous albinism, development of freckles, and mediation of female-specific mechanisms of analgesia. MC1R's natural agonists include a-melanocyte-stimulating hormone and corticotrophin (ACTH1-39), which are important components of hypothalamic pituitary adrenal axis and increase in response to stress. Given the multiple relevant roles of MC1R, we studied whether the MC1R gene would be associated with susceptibility to major depressive disorder or with response to antidepressant treatment.
关键词Antidepressant Association Haplotype Major Depression Melanocortin 1 Receptor Single Nucleotide Polymorphisms
资助信息University of Miami, Department of Psychiatry and Behavioral Sciences
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14467
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Ctr Drug Screening & Res, Beijing 100864, Yunnan, Peoples R China
3.Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA
4.Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA
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Wu, Gui-Sheng,Luo, Huai-Rong,Dong, Chuanhui,et al. Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response[J]. PSYCHIATRIC GENETICS,2011,21(1):14-18.
APA Wu, Gui-Sheng,Luo, Huai-Rong,Dong, Chuanhui,Mastronardi, Claudio,Licinio, Julio,&Wong, Ma-Li.(2011).Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response.PSYCHIATRIC GENETICS,21(1),14-18.
MLA Wu, Gui-Sheng,et al."Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response".PSYCHIATRIC GENETICS 21.1(2011):14-18.
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