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题名: Chemical Constituents of Dracocephalum forrestii
作者: Li, Su-Mei1, 3; Yang, Xian-Wen2, 3; Li, Yong-Li2; Shen, Yun-Heng2; Feng, Lin2; Wang, Yue-Hu1; Zeng, Hua-Wu2; Liu, Xiao-Hua2; Zhang, Chang-Sheng3; Long, Chun-Lin1; Zhang, Wei-Dong2
刊名: PLANTA MEDICA
关键词: Dracocephalum forrestii ; Lamiaceae ; phenylethanoids ; lignans ; RAW 264.7 macrophages ; NO
英文摘要: A systematic phytochemical examination of the whole plant Dracocephalum forrestii led to the isolation of 4 new and 65 known chemical constituents. By detailed 1D and 2D NMR spectroscopic analyses, the new compounds were identified as 4-hydroxy-3-methoxyphenylethanol 8-O-[(6-O-syringoyl)-beta-D-glucopyranoside] (1), 3,4,5-trimethoxyphenylethanol beta-D-glucopyranoside (2), 4-O-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl]phenylethylcinnamamide (3), and 9 ''-O-n-butyl lithospermate (4). The new isolates were evaluated for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Compound 2 revealed a moderate effect without any cytotoxicity under the assayed concentrations.
出版日期: 2009-12-01
卷号: 75, 期号:15, 页码:1591-1596
DOI标识: 10.1055/s-0029-1185868
语种: 英语
ISSN号: 0032-0943
资助信息: The authors wish to thank Professor Li-shang Xie in Kunming Institute of Botany, Chinese Academy of Sciences for identification of the plant. This research was Supported by Changjiang Scholars and Innovative Research Team in University (PCSIRT), NCET Foundation, NSFC (30725045), National 863 Program (2006AA02Z338), Shanghai Leading Academic Discipline Project (13906), and in part by the Ministry of Science and Technology of China (Nos. 2004DKA30430, 2005DKA21 006) and the Ministry of Education of China through its III Project (B08044, CUN 985-3-3).
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14071
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Second Mil Med Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China
3.Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Li, SM; Yang, XW; Li, YL; Shen, YH; Feng, L; Wang, YH; Zeng, HW; Liu, XH; Zhang, CS; Long, CL; Zhang, WD.Chemical Constituents of Dracocephalum forrestii,PLANTA MEDICA,2009,75(15):1591-1596
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