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题名: Crystal structure of a 1:1 complex of natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol
作者: Sun, HD; Qiu, SX; Lin, LZ; Zhang, RP; Zhou, YS; Zheng, QT; Johnson, ME; Fong, HHS; Farnsworth, NR; Cordell, GA
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: Diterp-Complex-RA (DCRA), a unique, inseparable, natural hydrogen-bonded 1:1 complex consisting of a novel diterpenoid neoangustifolin and a known diterpenoid epinodosinol, was isolated from Rabdosia angustifolia, along with daucosterol and the known diterpenes sodoponin, trichorabdal A, and cirsiliol. The binding mode of the complex and the absolute configuration of the two substrates were elucidated through X-ray crystallography. Unambiguous NMR data assignments were achieved by a combination of various 2D-NMR techniques. It was clearly demonstrated that DCRA consists of two different diterpene substrates that are bound together by an intermolecular hydrogen bond and the very good hydrophobic close approach of mutual matching surfaces. In addition, intramolecular hydrogen bonds also contribute to the stabilization of the complex.
出版日期: 1997-03-01
卷号: 60, 期号:3, 页码:203-206
语种: 英语
ISSN号: 0163-3864
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13843
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,CTR PHARMACEUT BIOTECHNOL,CHICAGO,IL 60612
2.CHINESE ACAD SCI,KUNMING INST BOT,KUNMING 650204,PEOPLES R CHINA
3.CHINESE ACAD MED SCI,INST MAT MED,BEIJING 100050,PEOPLES R CHINA

Recommended Citation:
Sun, HD; Qiu, SX; Lin, LZ; Zhang, RP; Zhou, YS; Zheng, QT; Johnson, ME; Fong, HHS; Farnsworth, NR; Cordell, GA.Crystal structure of a 1:1 complex of natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol,JOURNAL OF NATURAL PRODUCTS,1997,60(3):203-206
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