Crystal structure of a 1:1 complex of natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol
Sun, HD; Qiu, SX; Lin, LZ; Zhang, RP; Zhou, YS; Zheng, QT; Johnson, ME; Fong, HHS; Farnsworth, NR; Cordell, GA
1997-03-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号60期号:3页码:203-206
摘要Diterp-Complex-RA (DCRA), a unique, inseparable, natural hydrogen-bonded 1:1 complex consisting of a novel diterpenoid neoangustifolin and a known diterpenoid epinodosinol, was isolated from Rabdosia angustifolia, along with daucosterol and the known diterpenes sodoponin, trichorabdal A, and cirsiliol. The binding mode of the complex and the absolute configuration of the two substrates were elucidated through X-ray crystallography. Unambiguous NMR data assignments were achieved by a combination of various 2D-NMR techniques. It was clearly demonstrated that DCRA consists of two different diterpene substrates that are bound together by an intermolecular hydrogen bond and the very good hydrophobic close approach of mutual matching surfaces. In addition, intramolecular hydrogen bonds also contribute to the stabilization of the complex.
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别sci
语种英语
WOS记录号WOS:A1997WP60300001
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13843
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,CTR PHARMACEUT BIOTECHNOL,CHICAGO,IL 60612
2.CHINESE ACAD SCI,KUNMING INST BOT,KUNMING 650204,PEOPLES R CHINA
3.CHINESE ACAD MED SCI,INST MAT MED,BEIJING 100050,PEOPLES R CHINA
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Sun, HD,Qiu, SX,Lin, LZ,et al. Crystal structure of a 1:1 complex of natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol[J]. JOURNAL OF NATURAL PRODUCTS,1997,60(3):203-206.
APA Sun, HD.,Qiu, SX.,Lin, LZ.,Zhang, RP.,Zhou, YS.,...&Cordell, GA.(1997).Crystal structure of a 1:1 complex of natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol.JOURNAL OF NATURAL PRODUCTS,60(3),203-206.
MLA Sun, HD,et al."Crystal structure of a 1:1 complex of natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol".JOURNAL OF NATURAL PRODUCTS 60.3(1997):203-206.
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