Preparation of analogues of Territrem B, a potent AChE inhibitor

	Preparation of analogues of Territrem B, a potent AChE inhibitor
	Zhao, Y ; Ku, YL ; Hao, XJ; Lee, SS
	2000-11-03
发表期刊	TETRAHEDRON
卷号	56 期号:45 页码:8901-8913
摘要	The synthesis of analogues of the potent acetylcholinesterase inhibitor, Territrem B, was carried out starting from the naturally occurring jujubogenin glycosides. Dihydrojujubogenin-2-en-1-one (1), a dammarane derivative that possesses a skeleton and pharmacophore partially similar to those of Tenitrem B, was synthesized via three different paths. The derivative 21, which contains two potential pharmacophores, was also synthesized. The anti-AChE activity of the analogues was measured. The aromatic ring moiety seemed to be less important when compared with the 2-en-1-one pharmacophore. (C) 2000 Elsevier Science Ltd. All rights reserved.
关键词	Chemotherapy Enzyme Inhibitors Terpenes And Terpenoids Structure-activity
学科领域	Chemistry, Organic
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000090123900016
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13823
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China 2.Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10018, Taiwan
推荐引用方式 GB/T 7714	Zhao, Y,Ku, YL,Hao, XJ,et al. Preparation of analogues of Territrem B, a potent AChE inhibitor[J]. TETRAHEDRON,2000,56(45):8901-8913.
APA	Zhao, Y,Ku, YL,Hao, XJ,&Lee, SS.(2000).Preparation of analogues of Territrem B, a potent AChE inhibitor.TETRAHEDRON,56(45),8901-8913.
MLA	Zhao, Y,et al."Preparation of analogues of Territrem B, a potent AChE inhibitor".TETRAHEDRON 56.45(2000):8901-8913.

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