Preparation of analogues of Territrem B, a potent AChE inhibitor
Zhao, Y; Ku, YL; Hao, XJ; Lee, SS
Source PublicationTETRAHEDRON
AbstractThe synthesis of analogues of the potent acetylcholinesterase inhibitor, Territrem B, was carried out starting from the naturally occurring jujubogenin glycosides. Dihydrojujubogenin-2-en-1-one (1), a dammarane derivative that possesses a skeleton and pharmacophore partially similar to those of Tenitrem B, was synthesized via three different paths. The derivative 21, which contains two potential pharmacophores, was also synthesized. The anti-AChE activity of the analogues was measured. The aromatic ring moiety seemed to be less important when compared with the 2-en-1-one pharmacophore. (C) 2000 Elsevier Science Ltd. All rights reserved.
KeywordChemotherapy Enzyme Inhibitors Terpenes And Terpenoids Structure-activity
Subject AreaChemistry, Organic
Indexed BySCI ; IC
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000090123900016
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
2.Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10018, Taiwan
Recommended Citation
GB/T 7714
Zhao, Y,Ku, YL,Hao, XJ,et al. Preparation of analogues of Territrem B, a potent AChE inhibitor[J]. TETRAHEDRON,2000,56(45):8901-8913.
APA Zhao, Y,Ku, YL,Hao, XJ,&Lee, SS.(2000).Preparation of analogues of Territrem B, a potent AChE inhibitor.TETRAHEDRON,56(45),8901-8913.
MLA Zhao, Y,et al."Preparation of analogues of Territrem B, a potent AChE inhibitor".TETRAHEDRON 56.45(2000):8901-8913.
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