Studies on the synthesis of novel chalcone and biological activity

	Studies on the synthesis of novel chalcone and biological activity
	Liao, TG ; Wang, QA ; Fang, WQ ; Zhu, HJ
	2006-05-01
发表期刊	CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷号	26 期号:5 页码:685-689
摘要	Eight novel chalcone compounds 1a similar to 1h were synthesized by esterification, methoxymethyl protection or methylation, hydrazidation, oxidation, aldol condensation, deprotection, O-farnesylation or O-prenylation respectively using 3,5-dihydroxybenzoic acid as starting material in overall yields of 5.6%similar to 46%. Their structures were confirmed by H-1 NMR, C-13 NMR, IR and MS spectra. Target compounds were screened with three international standard models for biological activity. Results showed that 1b against model CAT-B and le against model CDC25 possessed the good inhibition activity.
关键词	Hydroxylated Chalcone Farnesyloxy Chalcone Prenyloxy Chalcone Synthesis Biological Activity
学科领域	Chemistry, Organic
收录类别	SCI
语种	英语
WOS记录号	WOS:000237683900015
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13747
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resource W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Liao, TG,Wang, QA,Fang, WQ,et al. Studies on the synthesis of novel chalcone and biological activity[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2006,26(5):685-689.
APA	Liao, TG,Wang, QA,Fang, WQ,&Zhu, HJ.(2006).Studies on the synthesis of novel chalcone and biological activity.CHINESE JOURNAL OF ORGANIC CHEMISTRY,26(5),685-689.
MLA	Liao, TG,et al."Studies on the synthesis of novel chalcone and biological activity".CHINESE JOURNAL OF ORGANIC CHEMISTRY 26.5(2006):685-689.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
20120718035.pdf（300KB）			开放获取	--	浏览下载