Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta

	Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta
	Li, L; Nie, JL ; Shen, ZQ ; Wu, WL ; Chen, ZH ; Hao, XJ
	2001-03-01
发表期刊	PLANTA MEDICA
卷号	67 期号:2 页码:142-145
摘要	The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var, acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were investigated. Intravenous spiramine T (0.38, 0.75, and 1.5 mg.kg(-1)) markedly reduced the stroke index, enhanced the recovery of EEG amplitude during reperfusion and decreased the concentrations of cortex calcium and LPO in a dose-dependent manner. However, no significant effects on water and sodium contents were observed. These results suggested that spiramine T exhibited protective effects on cerebral ischemia-reperfusion injury in gerbils, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation. This is the first report on spiramine T as a natural product with neuroprotective effects.
关键词	Spiraea Japonica Var Acuta Rosaceae Spiramine t Cerebral Ischemia-reperfusion Stroke Index Electroencephalogram Calcium Lipid Peroxide
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000167827400009
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13635
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Li, L,Nie, JL,Shen, ZQ,et al. Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta[J]. PLANTA MEDICA,2001,67(2):142-145.
APA	Li, L,Nie, JL,Shen, ZQ,Wu, WL,Chen, ZH,&Hao, XJ.(2001).Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta.PLANTA MEDICA,67(2),142-145.
MLA	Li, L,et al."Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta".PLANTA MEDICA 67.2(2001):142-145.

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