Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta
Li, L; Nie, JL; Shen, ZQ; Wu, WL; Chen, ZH; Hao, XJ
2001-03-01
发表期刊PLANTA MEDICA
卷号67期号:2页码:142-145
摘要The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var, acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were investigated. Intravenous spiramine T (0.38, 0.75, and 1.5 mg.kg(-1)) markedly reduced the stroke index, enhanced the recovery of EEG amplitude during reperfusion and decreased the concentrations of cortex calcium and LPO in a dose-dependent manner. However, no significant effects on water and sodium contents were observed. These results suggested that spiramine T exhibited protective effects on cerebral ischemia-reperfusion injury in gerbils, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation. This is the first report on spiramine T as a natural product with neuroprotective effects.
关键词Spiraea Japonica Var Acuta Rosaceae Spiramine t Cerebral Ischemia-reperfusion Stroke Index Electroencephalogram Calcium Lipid Peroxide
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000167827400009
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13635
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
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Li, L,Nie, JL,Shen, ZQ,et al. Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta[J]. PLANTA MEDICA,2001,67(2):142-145.
APA Li, L,Nie, JL,Shen, ZQ,Wu, WL,Chen, ZH,&Hao, XJ.(2001).Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta.PLANTA MEDICA,67(2),142-145.
MLA Li, L,et al."Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta".PLANTA MEDICA 67.2(2001):142-145.
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