| Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin | |
Shen, ZQ; Dong, ZJ ; Peng, H; Liu, JK
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| 2003-12-01 | |
| 发表期刊 | PLANTA MEDICA
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| ISSN | 0032-0943 |
| 卷号 | 69期号:12页码:1109-1112 |
| 摘要 | In this study, Charlton's and Tornihisa's methods were modified to investigate the thrombolytic effect of corilagin from the Chinese herbal plant Phyllanthus urinaria L., as well as its effect on carotid artery patency status. The activity of type 1 plasminogen activator inhibitor (PAI-1) in rat plasma or platelet-released substances and tissue-type plasminogen activator (tPA) in rat plasma was assayed by use of a chromogenic substrate. The results showed that corilagin had a dose-dependent thrombolytic effect in rats. 5 mg/kg of corilagin produced a nearly similar reperfusion rate to that of 20 000 U/kg of urokinase, whereas it produced a lower reocclusion rate than urokinase. Corilagin significantly inhibited PAI-1 activity in rat plasma or platelet-released substances while it elevated plasma tPA activity, in a concentration-dependent manner. Corilagin, however, had no influence on rabbit platelet aggregation. It is indicated that corilagin inhibited PAI-1 activity and increased tPA activity, and this property of corilagin is assumed to be responsible for the thrombolytic effect. |
| 关键词 | Corilagin Thrombolysis Type 1 Plasminogen Activator Inhibitor Tissue-type Plasminogen Activator Phyllanthus Urinaria Euphorbiaceae |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000188883400008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/13627 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, ZQ,Dong, ZJ,Peng, H,et al. Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin[J]. PLANTA MEDICA,2003,69(12):1109-1112. |
| APA | Shen, ZQ,Dong, ZJ,Peng, H,&Liu, JK.(2003).Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin.PLANTA MEDICA,69(12),1109-1112. |
| MLA | Shen, ZQ,et al."Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin".PLANTA MEDICA 69.12(2003):1109-1112. |
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