Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin
Shen, ZQ; Dong, ZJ; Peng, H; Liu, JK
2003-12-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号69期号:12页码:1109-1112
摘要In this study, Charlton's and Tornihisa's methods were modified to investigate the thrombolytic effect of corilagin from the Chinese herbal plant Phyllanthus urinaria L., as well as its effect on carotid artery patency status. The activity of type 1 plasminogen activator inhibitor (PAI-1) in rat plasma or platelet-released substances and tissue-type plasminogen activator (tPA) in rat plasma was assayed by use of a chromogenic substrate. The results showed that corilagin had a dose-dependent thrombolytic effect in rats. 5 mg/kg of corilagin produced a nearly similar reperfusion rate to that of 20 000 U/kg of urokinase, whereas it produced a lower reocclusion rate than urokinase. Corilagin significantly inhibited PAI-1 activity in rat plasma or platelet-released substances while it elevated plasma tPA activity, in a concentration-dependent manner. Corilagin, however, had no influence on rabbit platelet aggregation. It is indicated that corilagin inhibited PAI-1 activity and increased tPA activity, and this property of corilagin is assumed to be responsible for the thrombolytic effect.
关键词Corilagin Thrombolysis Type 1 Plasminogen Activator Inhibitor Tissue-type Plasminogen Activator Phyllanthus Urinaria Euphorbiaceae
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000188883400008
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被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13627
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
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Shen, ZQ,Dong, ZJ,Peng, H,et al. Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin[J]. PLANTA MEDICA,2003,69(12):1109-1112.
APA Shen, ZQ,Dong, ZJ,Peng, H,&Liu, JK.(2003).Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin.PLANTA MEDICA,69(12),1109-1112.
MLA Shen, ZQ,et al."Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin".PLANTA MEDICA 69.12(2003):1109-1112.
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