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题名: Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin
作者: Shen, ZQ; Dong, ZJ; null(彭华); Liu, JK
刊名: PLANTA MEDICA
关键词: corilagin ; thrombolysis ; type 1 plasminogen activator inhibitor ; tissue-type plasminogen activator ; Phyllanthus urinaria ; Euphorbiaceae
英文摘要: In this study, Charlton's and Tornihisa's methods were modified to investigate the thrombolytic effect of corilagin from the Chinese herbal plant Phyllanthus urinaria L., as well as its effect on carotid artery patency status. The activity of type 1 plasminogen activator inhibitor (PAI-1) in rat plasma or platelet-released substances and tissue-type plasminogen activator (tPA) in rat plasma was assayed by use of a chromogenic substrate. The results showed that corilagin had a dose-dependent thrombolytic effect in rats. 5 mg/kg of corilagin produced a nearly similar reperfusion rate to that of 20 000 U/kg of urokinase, whereas it produced a lower reocclusion rate than urokinase. Corilagin significantly inhibited PAI-1 activity in rat plasma or platelet-released substances while it elevated plasma tPA activity, in a concentration-dependent manner. Corilagin, however, had no influence on rabbit platelet aggregation. It is indicated that corilagin inhibited PAI-1 activity and increased tPA activity, and this property of corilagin is assumed to be responsible for the thrombolytic effect.
出版日期: 2003-12-01
卷号: 69, 期号:12, 页码:1109-1112
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13627
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China

Recommended Citation:
Shen, ZQ; Dong, ZJ; Peng, H; Liu, JK.Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin,PLANTA MEDICA,2003,69(12):1109-1112
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