| Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica | |
Du, ZZ ; Zhu, N; Ze-Ren-Wang-Mu, N; Shen, YM
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| 2003-06-01 | |
| 发表期刊 | PLANTA MEDICA
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| ISSN | 0032-0943 |
| 卷号 | 69期号:6页码:547-551 |
| 摘要 | Bioassay-guided fractionation of the ethanol extract of the aerial parts of Clematis tangutica led to the isolation of two new antifungal triterpene saponins. Their structures were determined to be 3-O-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl ester (1) and 3-O-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl ester (2) on the basis of spectral data and chemical evidence. Inhibitory activities of the two saponins against seven fungal strains were evaluated. Compounds 1 and 2 showed evident antifungal activity (MIA approximate to 2.5 mug/disc) against Saccharomyces cerevisiae, similar to the positive control amphotericin B and ordinary activities (MIA approximate to 10 mug/disc) against Penicillium avellaneum UC-4376, Candida glabrata, Trichosporon beigelii and Pyricularia oryzae. Compound 2 is a better antifungal agent than compound 1 against most of the fungal strains that were tested. |
| 关键词 | Clematis Tangutica Ranunculaceae Triterpene Saponin Hederagenin Antifungal Activity |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000184144600013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/13625 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Tibeten Inst Plateau Biol, Lasha, Tibet, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, ZZ,Zhu, N,Ze-Ren-Wang-Mu, N,et al. Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica[J]. PLANTA MEDICA,2003,69(6):547-551. |
| APA | Du, ZZ,Zhu, N,Ze-Ren-Wang-Mu, N,&Shen, YM.(2003).Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica.PLANTA MEDICA,69(6),547-551. |
| MLA | Du, ZZ,et al."Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica".PLANTA MEDICA 69.6(2003):547-551. |
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