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题名: Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica
作者: null(杜芝芝); Zhu, N; Ze-Ren-Wang-Mu, N; Shen, YM
刊名: PLANTA MEDICA
关键词: Clematis tangutica ; Ranunculaceae ; triterpene saponin ; hederagenin ; antifungal activity
英文摘要: Bioassay-guided fractionation of the ethanol extract of the aerial parts of Clematis tangutica led to the isolation of two new antifungal triterpene saponins. Their structures were determined to be 3-O-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl ester (1) and 3-O-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl ester (2) on the basis of spectral data and chemical evidence. Inhibitory activities of the two saponins against seven fungal strains were evaluated. Compounds 1 and 2 showed evident antifungal activity (MIA approximate to 2.5 mug/disc) against Saccharomyces cerevisiae, similar to the positive control amphotericin B and ordinary activities (MIA approximate to 10 mug/disc) against Penicillium avellaneum UC-4376, Candida glabrata, Trichosporon beigelii and Pyricularia oryzae. Compound 2 is a better antifungal agent than compound 1 against most of the fungal strains that were tested.
出版日期: 2003-06-01
卷号: 69, 期号:6, 页码:547-551
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13625
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Tibeten Inst Plateau Biol, Lasha, Tibet, Peoples R China

Recommended Citation:
Du, ZZ; Zhu, N; Ze-Ren-Wang-Mu, N; Shen, YM.Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica,PLANTA MEDICA,2003,69(6):547-551
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