Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica
Du, ZZ; Zhu, N; Ze-Ren-Wang-Mu, N; Shen, YM
2003-06-01
Source PublicationPLANTA MEDICA
ISSN0032-0943
Volume69Issue:6Pages:547-551
AbstractBioassay-guided fractionation of the ethanol extract of the aerial parts of Clematis tangutica led to the isolation of two new antifungal triterpene saponins. Their structures were determined to be 3-O-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl ester (1) and 3-O-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl ester (2) on the basis of spectral data and chemical evidence. Inhibitory activities of the two saponins against seven fungal strains were evaluated. Compounds 1 and 2 showed evident antifungal activity (MIA approximate to 2.5 mug/disc) against Saccharomyces cerevisiae, similar to the positive control amphotericin B and ordinary activities (MIA approximate to 10 mug/disc) against Penicillium avellaneum UC-4376, Candida glabrata, Trichosporon beigelii and Pyricularia oryzae. Compound 2 is a better antifungal agent than compound 1 against most of the fungal strains that were tested.
KeywordClematis Tangutica Ranunculaceae Triterpene Saponin Hederagenin Antifungal Activity
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000184144600013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/13625
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Tibeten Inst Plateau Biol, Lasha, Tibet, Peoples R China
Recommended Citation
GB/T 7714
Du, ZZ,Zhu, N,Ze-Ren-Wang-Mu, N,et al. Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica[J]. PLANTA MEDICA,2003,69(6):547-551.
APA Du, ZZ,Zhu, N,Ze-Ren-Wang-Mu, N,&Shen, YM.(2003).Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica.PLANTA MEDICA,69(6),547-551.
MLA Du, ZZ,et al."Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica".PLANTA MEDICA 69.6(2003):547-551.
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