Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions

	Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions
	Shen, ZQ ; Dong, ZJ; Cheng, P ; Li, L; Chen, ZH ; Liu, J
	2003-07-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	69 期号:7 页码:605-609
摘要	The effects of plumbagin were investigated on platelet aggregation in vitro and ex vivo, on the binding of thrombin-stimulated platelets to neutrophils, and platelet aggregation induced by intact neutrophils and N-formyt-methionyl-leucyl-phenylalanine (fMLP) or platelet activating factor (PAF) activated neutrophils, by use of the methods of Hamburger, McEver and Born, respectively. The results showed that plumbagin in vitro significantly inhibited adenosine diphosphate (ADP)-, arachidonic acid (AA)-, or platelet activating factor (PAF)-induced platelet aggregation, in a concentration-dependent manner. The medium inhibitory concentrations (IC50) were 39.4, 82.7 and 38.1 muM respectively. Intragastric plumbagin at 10 mg/kg markedly suppressed platelet aggregation induced by ADP, AA, or PAF. Plumbagin decreased the binding between thrombin-stimulated platelets and neutrophils with an IC50 of 62.9 muM. Plumbagin significantly inhibited washed platelet aggregation stimulated by fMLP- or PAF-activated neutrophils. The IC50 values were 54.3 and 47.6 muM, respectively. On the other hand, plumbagin and aspirin increased the inhibition of intact neutrophils on AA-induced platelet aggregation. It is suggested that plumbagin inhibited platelet aggregation in vitro and ex vivo, suppressed the binding of activated platelets to neutrophils, inhibited platelet aggregation induced by activated neutrophils, and increased inhibition of intact neutrophils on platelet reactivity.
关键词	Plumbagin Platelet Aggregation Platelet-neutrophil Interactions
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000184890000003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13621
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Shen, ZQ,Dong, ZJ,Cheng, P,et al. Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions[J]. PLANTA MEDICA,2003,69(7):605-609.
APA	Shen, ZQ,Dong, ZJ,Cheng, P,Li, L,Chen, ZH,&Liu, J.(2003).Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions.PLANTA MEDICA,69(7),605-609.
MLA	Shen, ZQ,et al."Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions".PLANTA MEDICA 69.7(2003):605-609.

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